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硒化玉米须多糖通过抑制NLRP3-GSDMD信号通路减少草酸钙晶体诱导的细胞焦亡
Authors Han J, Tong XY , Zheng YY, Cheng JH, Ouyang JM , Li K
Received 30 November 2024
Accepted for publication 13 February 2025
Published 12 March 2025 Volume 2025:18 Pages 3623—3638
DOI https://doi.org/10.2147/JIR.S506093
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Ning Quan
摘要：采用COM-3μm损伤HK-2细胞建立细胞焦亡模型，采用硒化前后玉米须多糖(DCSP，Se-DCSP)抑制焦亡。结果表明DCSP 和Se-DCSP可以通过减少细胞损伤和氧化应激降低细胞焦亡相关炎症因子IL-1β/18的分泌，下调 Caspase-1、NLRP3、GSDMD和TNF-α的表达，修复损伤细胞，从而抑制HK-2细胞焦亡，且硒化多糖的抑制作用比硒化前显著增强。Se-DCSP 可通过NLRP3/Caspase-1/GSDMD/IL-1β/18信号通路抑制细胞焦亡，从而降低肾结石的形成风险。
作者：韩锦，童鑫一，郑雨云，程佳慧，欧阳健明*，李可*。