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外用中药联合尿素软膏治疗瑞戈非尼所致手足皮肤反应1例并文献复习
Authors Liu ZN , Shen YL, Dong HJ, Tan KX, Li J, Peng YM, Cui HJ
Received 6 December 2024
Accepted for publication 31 March 2025
Published 9 April 2025 Volume 2025:18 Pages 509—519
DOI https://doi.org/10.2147/OTT.S510766
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Sanjay Singh
瑞戈非尼是一种多激酶抑制剂类药物，常引起严重的手足皮肤反应。手足皮肤反应是导致治疗减量或停药的常见原因。本文报道一例外用中药“手足平”泡洗联合尿素软膏有效治疗纤维粘液样肉瘤患者的HSFR，表现了中西医结合治疗手足皮肤反应的独特优势。并进一步对靶向药相关手足皮肤反应的临床特征、发病机制和防治策略进行文献综述，以期为临床提供有益的参考。