Xu-Ting Peng,1 Zhu-Hua Cai,2 Jie Shen,3 Hai-Yan Zhu2 

1Department of Gynecology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 2Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 3Department of Ultrasound, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China

Correspondence: Hai-Yan Zhu, Email vek410@yeah.net

Objective: To explore the application value of low molecular weight heparin combined with heparin in patients with chorionic bump in early pregnancy.
Methods: This retrospective study collected 86 cases of patients with early pregnancy complicated by chorionic bump treated in our hospital from January 2020 to February 2022. According to the treatment methods, the patients were divided into the combined treatment group (n=41) and the control group (n=45). Patients in the combined treatment group were treated with oral prednisone combined with low molecular weight heparin injection, while patients in the control group received no additional treatment. The changes and differences in chorionic size, serum hormone levels, and uterine artery blood flow parameters before treatment and at 1 month and 2 months after treatment were compared between the two groups. The pregnancy outcomes and adverse reaction rates were also analyzed.
Results: At 1 month and 2 months after treatment, the average size of the chorionic bump in the combined treatment group was significantly smaller than before treatment and the control group (P< 0.05). Two months after treatment, the average levels of E2, P, and LH in the combined treatment group were significantly higher, and the average FSH level was significantly lower than those before treatment and in the control group (P< 0.05). At 1 month and 2 months after treatment, the average RI in the combined treatment group was significantly lower than before treatment and the control group, and although the average S/D ratio was higher than before treatment, it was still lower than that of the control group (P< 0.05). The incidence of adverse pregnancy outcomes in the combined treatment group was significantly lower than that in the control group (χ²/P=5.469/0.019). There was no significant difference in the incidence of adverse reactions between the two groups (χ²/P=0.613/0.434).
Conclusion: Prednisone combined with low molecular weight heparin can effectively reduce the size of the chorionic bump, improve uterine artery blood flow parameters, and ultimately lower the risk of adverse pregnancy outcomes in patients with early pregnancy complicated by chorionic bump. This treatment approach has reliable clinical safety and holds potential for broader application in such patients.

Keywords: early pregnancy, chorionic bump, prednisone, low molecular weight heparin, pregnancy outcomes