Di Xia,* Zhouliang Liu,* Jiamin Li, Jingjing Liu, Yongbin Qu

Dermatology Hospital of Southern Medical University, Southern Medical University, Guangzhou, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Di Xia, Dermatology Hospital of Southern Medical, University, No. 2, Lujing Road, Yuexiu District2, Lujing Road, Yuexiu District, Guangzhou City, Guangdong Province, 510091, People’s Republic of China, Email xiadi_smu@163.com

Abstract: Necrolytic migratory erythema(NME) is a rare dermatitis usually associated with pancreatic neuroendocrine tumor as a manifestation of glucogonoma syndrome. Over the past five years, NME has been scarcely reported in the literature, with only 8 cases globally. The age range of affected individuals spans from 28 to 62 years, with a mean onset age of 49.4 years. This report presents a 41-year-old male diagnosed with NME secondary to glucagonoma, highlighting the critical need for heightened clinical vigilance in younger NME patients. And NME can mimic other dermatological conditions, leading to potential misdiagnosis and late tumor identification. This case highlights the typical clinical features, aiming to enhance the diagnostic efficiency and accuracy for NME.

Keywords: necrolytic migratory erythema, glucagonoma, neuroendocrine tumor, pancreatic neuroendocrine tumor, rare dermatologic presentation