Shuang Liu,1 Linqi Cheng,2 Sen Li3 

1The Reproductive Laboratory, Shenyang, People’s Republic of China; 2Department of Biotechnology, Shenyang Medical College, Shenyang, People’s Republic of China; 3The Central Laboratory, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

Correspondence: Shuang Liu, Email liushuang929@yeah.net

Abstract: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder that has garnered attention in recent years for its intricate relationship with gut microbiota, which plays a significant role in the metabolic abnormalities associated with this condition. This review focuses on the characteristics of gut microbiota in polycystic ovary syndrome (PCOS). By analyzing current literature, we will focus on the alterations in gut microbiota composition, influential factors, and the pathophysiological mechanisms linking gut microbiota and PCOS, diagnostic approaches, therapeutic strategies, as well as controversies and future directions in this field are discussed. Understanding these relationships may provide insights into the disease mechanism and highlight novel treatment strategies for managing PCOS.

Keywords: polycystic ovary syndrome, gut microbiota, metabolic abnormalities, microbiome, endocrine disorders