Congkuan Song,1– 3 Zhen-Juan Liu,4 Bangjun Xu,5 Rui Zou,1,2 Weidong Hu1– 3 

1Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Hubei Provincial Clinical Research Center for Cancer, Wuhan, People’s Republic of China; 3Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, People’s Republic of China; 4Department of Critical Care Medicine, Qingdao Hospital, University of Health Rehabilitation Sciences(Qingdao Municipal Hospital), Qingdao, People’s Republic of China; 5Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China

Correspondence: Weidong Hu, Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, People’s Republic of China, Email huwd@whu.edu.cn

Abstract: Uridine plays a major role as a key biomolecule in health maintenance and disease treatment. Here, we comb and summarize a large amount of data on the important role of uridine in health, disease and treatment in the past 30 years, conduct a comprehensive and in-depth discussion, and give unique insights and overview on the current situation and difficulties of the application of uridine in disease treatment. The review aims to provide new perspectives and implications for uridine research and to promote further application of uridine in the medical field.

Keywords: uridine, uridine homeostasis, uridine catabolism