Zi-Yi Shen, Jie Wang, Xiao-Ping Shen, Bao-Qin Xv, Dan-Ping Shen

Department of Anesthesiology, Suzhou Ninth People’s Hospital, Suzhou, People’s Republic of China

Correspondence: Dan-Ping Shen, Email cjs855@yeah.net

Objective: To compare the effects of intravenous anesthesia with propofol and inhalation anesthesia with sevoflurane on coagulation and immune system function in patients undergoing radical surgery for colon cancer.
Methods: The following were compared between the two groups: blood rheology indicators [plasma viscosity (PV), erythrocyte aggregation index (EAI), erythrocyte deformability index (EDI)], coagulation function indicators [prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer (D-D), fibrinogen (FIB)], humoral immune function indicators [immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG)], cellular immune function indicators [CD4+, CD8+, natural killer cells (NK)], postoperative recovery, and postoperative complications.
Results: ① Blood Rheology Indicators: At 60 minutes after anesthesia induction, PV, EAI, and EDI levels in both groups decreased compared to pre-anesthesia levels (P < 0.05), with no significant differences between the two groups at the same time point (P > 0.05). ② Coagulation Function Indicators: At 1 day postoperatively, D-D and FIB levels increased compared to 1 day preoperatively, with Group A showing less pronounced changes than Group B (P < 0.05). ③ Humoral Immune Function Indicators: In Group A, humoral immune indicators showed no significant changes at 1 day postoperatively compared to 1 day preoperatively (P > 0.05). In Group B, IgM and IgG levels decreased at 1 day postoperatively compared to 1 day preoperatively and were lower than those in Group A at the same time point (P < 0.05). ④ Cellular Immune Function Indicators: At 1 day postoperatively, CD4+, CD8+, and NK cell levels decreased in both groups compared to 1 day preoperatively.
Conclusion: Propofol and sevoflurane have similar effects on perioperative blood rheology in colon cancer patients. However, propofol has a lesser impact on coagulation and immune function compared to sevoflurane, making it more effective in promoting postoperative recovery and reducing the risk of related postoperative complications.

Keywords: colon cancer, radical surgery, propofol, sevoflurane, coagulation function, immune system function, effects