Zheng Yang,1,2 Shaobo Zhai,1,2 Yang Liu,1,2 Yuchuan Wu,1,2 Tianming He,1,2 Xiaolu Shi,1,2 Shunli Chu1,2 

1Hospital of Stomatology, Jilin University, Changchun, Jilin, 130021, People’s Republic of China; 2Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, Jilin, 130021, People’s Republic of China

Correspondence: Shunli Chu, Stomatological Hospital of Jilin University, Chaoyang District, Changchun, Jilin, 130021, People’s Republic of China, Email chusl@jlu.edu.cn

Abstract: Sticky bone is a new type of composite biological material in the field of dental implantation and restoration in recent years, which is usually composed of Autologous Fibrin Glue (AFG) or injectable-platelet rich fibrin (i-PRF) is prepared in combination with different types of bone augmentation materials, such as granular or powdered bone substitutes, providing a solution for bone regeneration that integrates growth factor release with bone scaffold functionality. Its unique gel texture ensures precise adhesion at the site of bone defects and does not fall apart due to external forces. This property not only enhances the stability of the bone graft, but also accelerates the regeneration and healing of bone tissue by providing an ideal environment for cell attachment and proliferation. In addition, the bioactivity and plasticity of sticky bone allow it to demonstrate higher adaptability and surgical success when compared to conventional bone grafting methods. Its development potential in bone tissue engineering also opens up new directions for future clinical applications. Overall, sticky bone is becoming a key material for promoting bone regeneration and improving implant success due to its sticky bone, scaffolding function and ability to carry bioactive components. In this paper aims to review the composition, preparation methods, mechanisms of action, and specific applications of sticky bone in oral implantation and related fields.

Keywords: sticky bone, platelet concentrates, bone substitutes, bone regeneration