Yi Ming Chu, Hong Zhang, Yeqiu Huang, Jia Li, Minmin Huang

Department of Critical Care Medicine, Haimen District People’s Hospital, Nantong, 226001, People’s Republic of China

Correspondence: Minmin Huang, Department of Critical Care Medicine, Haimen District People’s Hospital, Nantong, 226001, People’s Republic of China, Email huangminmin1983@163.com

Abstract: Healthcare systems worldwide face a significant challenge from nosocomial infections. These infections are associated with increased rates of disease, mortality, and healthcare expenses. Common issues with traditional treatment approaches include antibiotic resistance and inadequate pathogen targeting. Utilizing nanoparticles for the targeted administration of antimicrobial medications to infection areas has proven to enhance treatment outcomes while maintaining biocompatibility. Traditional diagnostic methods still rely on microbiological culture and susceptibility testing, while molecular technologies are seeing increased usage for rapid diagnosis. This review mainly aims to draw attention to the present state of nosocomial infections by outlining their prevalence and the ways in which nanotechnology is used to treat these illnesses. This study provides a thorough examination of the nanotherapeutic methods that have recently developed, with an emphasis on the clinical implications of different types of nanoparticles for the purpose of reducing the prevalence of nosocomial infectious diseases.

Keywords: intensive care units, nosocomial infections, nanomedicine, inorganic nanoparticles, organic nanoparticles