Li Lin, Ruzhi Zhang

Department of Dermatology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, People’s Republic of China

Correspondence: Ruzhi Zhang, Email zhangruzhi628@163.com

Abstract: Severe varicella is relatively rare in adults and may lead to death. Our case report describes a 36-year-old man with generalized papules and vesicles. The diagnosis was severe varicella, tinea cruris and type 2 diabetes. Generalized rash of severe varicella is very rare in clinically. In this patient, three days after the appearance of the rash, the CD4+T/CD8+T ratio increased, as did the serum levels of IFN-γ, TNF-α, and IL-17A, suggesting that the balance of the immune system was disturbed and there was an increased likelihood of viral infection, which may be related to the generalized spread of the lesions. The patient was discharged from the hospital after 2 weeks of antiviral treatment along with hepatoprotective, hypoglycemic and antifungal treatment of the buttocks with the lesions significantly reduced.

Keywords: generalized, varicella, diabetes