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已发表论文
聚多卡醇泡沫硬化剂注射治疗抗凝治疗合并混合痔出血患者的应用：一项回顾性单中心病例系列及文献综述（附视频）
Authors Li Z, Liu H, Ding W, Wang S, Lv L, Li X, Ding H
Received 8 July 2025
Accepted for publication 3 October 2025
Published 23 October 2025 Volume 2025:19 Pages 3251—3260
DOI https://doi.org/10.2147/PPA.S551867
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Johnny Chen
Zhen Li,* Hailong Liu,* Wenjing Ding,* Song Wang,* Liang Lv, Xiaobin Li, Haibo Ding
Department of General Surgery, Yangpu Hospital of Tongji University, Shanghai, 200090, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Haibo Ding, Department of General Surgery, Yangpu Hospital of Tongji University, 450 Tengyue Road, Shanghai, 200090, People’s Republic of China, Tel +86-18317166106, Email 2812097576@qq.com
Purpose: For patients with antithrombotic therapy combined with mixed hemorrhoid bleeding, the contradiction between antithrombotic and hemostatic treatments often requires surgical intervention. However, multi-country guidelines recommend the use of injection sclerotherapy (IST), but there is little research on the application of polidocanol foam IST. The purpose of this study is to explore the retrospective single-center case series experience of polidocanol foam IST in those patients and review the related literature.
Patients and Methods: From March 2018 to May 2023, we retrospectively analyzed the clinical data of 7 patients with mixed hemorrhoid bleeding in the General Surgery Department of Yangpu Hospital affiliated with Tongji University. These patients all received antithrombotic treatment and their bleeding could not be stopped by conservative treatment. Finally, they all received polidocanol foam IST. We summarized the single-center clinical application experience of polidocanol foam IST in those patients. Through a literature search, the related literature concerning the application of polidocanol foam IST in patients with antithrombotic therapy combined with mixed hemorrhoid bleeding were reviewed.
Results: Seven patients were successfully treated with polidocanol foam IST, and the bleeding stopped. The operation time ranged from 10– 30 minutes, and no serious complications occurred. At the 4-week postoperative follow-up evaluation, none of the patients had bleeding again, and hemoglobin significantly increased (106.0± 17.4 g/L vs 70.9± 19.7 g/L, p=0.004). Four weeks after surgery, the overall clinical efficacy rate reached 100%, with a satisfaction rate of 100%. Through a literature review, three studies were ultimately included for analysis.
Conclusion: Polidocanol foam IST is a relatively safe and effective method for patients receiving antithrombotic therapy combined with mixed hemorrhoid bleeding. However, larger multicenter prospective studies are needed before this is the preferred treatment for such patients.
Keywords: polidocanol foam sclerotherapy, antithrombotic therapy, bleeding, hemorrhoids
Department of General Surgery, Yangpu Hospital of Tongji University, Shanghai, 200090, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Haibo Ding, Department of General Surgery, Yangpu Hospital of Tongji University, 450 Tengyue Road, Shanghai, 200090, People’s Republic of China, Tel +86-18317166106, Email 2812097576@qq.com
Purpose: For patients with antithrombotic therapy combined with mixed hemorrhoid bleeding, the contradiction between antithrombotic and hemostatic treatments often requires surgical intervention. However, multi-country guidelines recommend the use of injection sclerotherapy (IST), but there is little research on the application of polidocanol foam IST. The purpose of this study is to explore the retrospective single-center case series experience of polidocanol foam IST in those patients and review the related literature.
Patients and Methods: From March 2018 to May 2023, we retrospectively analyzed the clinical data of 7 patients with mixed hemorrhoid bleeding in the General Surgery Department of Yangpu Hospital affiliated with Tongji University. These patients all received antithrombotic treatment and their bleeding could not be stopped by conservative treatment. Finally, they all received polidocanol foam IST. We summarized the single-center clinical application experience of polidocanol foam IST in those patients. Through a literature search, the related literature concerning the application of polidocanol foam IST in patients with antithrombotic therapy combined with mixed hemorrhoid bleeding were reviewed.
Results: Seven patients were successfully treated with polidocanol foam IST, and the bleeding stopped. The operation time ranged from 10– 30 minutes, and no serious complications occurred. At the 4-week postoperative follow-up evaluation, none of the patients had bleeding again, and hemoglobin significantly increased (106.0± 17.4 g/L vs 70.9± 19.7 g/L, p=0.004). Four weeks after surgery, the overall clinical efficacy rate reached 100%, with a satisfaction rate of 100%. Through a literature review, three studies were ultimately included for analysis.
Conclusion: Polidocanol foam IST is a relatively safe and effective method for patients receiving antithrombotic therapy combined with mixed hemorrhoid bleeding. However, larger multicenter prospective studies are needed before this is the preferred treatment for such patients.
Keywords: polidocanol foam sclerotherapy, antithrombotic therapy, bleeding, hemorrhoids