111732
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
小儿室上性心动过速中丙泊酚、瑞马唑仑和环泊酚对心律失常诱发性的比较：一项回顾性研究
Authors Zhang X , Zhang N , Wang K, Ren Y
Received 10 June 2025
Accepted for publication 1 October 2025
Published 14 October 2025 Volume 2025:19 Pages 9321—9329
DOI https://doi.org/10.2147/DDDT.S537100
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Professor Anastasios Lymperopoulos
Xu Zhang,1,* Ning Zhang,2,* Kuiliang Wang,3 Yueyi Ren3
1Department of Anesthesiology, Peking University People’s Hospital, Qingdao; Women and Children’s Hospital, Qingdao University, Qingdao, People’s Republic of China; 2Department of Laboratory Medicine, Qingdao Women’s and Children’s Hospital Afftiliated to Qingdao University, Qingdao, People’s Republic of China; 3Department of Anesthesiology, Qingdao Women’s and Children’s Hospital Afftiliated to Qingdao University, Qingdao, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yueyi Ren, Email xxgmz1173@126.com Kuiliang Wang, Email wkl0532@126.com
Purpose: Propofol is a commonly used intravenous anesthetic in pediatric patients. Ciprofol and remimazolam, newly approved agents, cause minimal injection pain and demonstrate stable hemodynamic characteristics. This study aimed to evaluate their effects on arrhythmia inducibility in pediatric supraventricular tachycardia (SVT).
Patients and Methods: A retrospective analysis was conducted on the clinical data of pediatric patients with supraventricular tachycardia who underwent radiofrequency ablation under general anesthesia from May 2020 to June 2024. After excluding 28 cases, 173 patients were deemed eligible for analysis. According to the intravenous anesthesia drugs administered, the patients were classified into the propofol group (Group P), the ciprofol group (Group C), and the remimazolam group (Group R). The primary outcome measure was the arrhythmia inducibility, while the secondary outcome measures encompassed ablation success, extubation time, bispectral index (BIS) value, peri - operative relevant parameters, and the incidence of postoperative nausea and vomiting.
Results: No significant difference was observed in the arrhythmia inducibility among the three groups (97.40% vs 95.35% vs 94.34%) (P> 0.05). The secondary outcome measures in the three groups, including ablation success (P > 0.05), isoprenaline use (P > 0.05), recurrence (P > 0.05) and operation time (P > 0.05), were similar. Additionally, there was no significant difference in the incidence rates of nausea and vomiting. Excluding the baseline BIS, the Bispectral Index values of Group R were significantly higher than those of Group P and Group C at the same time point (P< 0.05). Moreover, the extubation time in Group R was shorter than that in Group P and Group C.
Conclusion: The effects of ciprofol and remimazolam on arrhythmia inducibility in pediatric supraventricular tachycardia were comparable to those of propofol. Both ciprofol and remimazolam are appropriate for radiofrequency ablation of supraventricular tachycardia in pediatric patients.
Keywords: arrhythmia inducibility, ciprofol, pediatric, radiofrequency ablation, remimazolam, supraventricular tachycardia
1Department of Anesthesiology, Peking University People’s Hospital, Qingdao; Women and Children’s Hospital, Qingdao University, Qingdao, People’s Republic of China; 2Department of Laboratory Medicine, Qingdao Women’s and Children’s Hospital Afftiliated to Qingdao University, Qingdao, People’s Republic of China; 3Department of Anesthesiology, Qingdao Women’s and Children’s Hospital Afftiliated to Qingdao University, Qingdao, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yueyi Ren, Email xxgmz1173@126.com Kuiliang Wang, Email wkl0532@126.com
Purpose: Propofol is a commonly used intravenous anesthetic in pediatric patients. Ciprofol and remimazolam, newly approved agents, cause minimal injection pain and demonstrate stable hemodynamic characteristics. This study aimed to evaluate their effects on arrhythmia inducibility in pediatric supraventricular tachycardia (SVT).
Patients and Methods: A retrospective analysis was conducted on the clinical data of pediatric patients with supraventricular tachycardia who underwent radiofrequency ablation under general anesthesia from May 2020 to June 2024. After excluding 28 cases, 173 patients were deemed eligible for analysis. According to the intravenous anesthesia drugs administered, the patients were classified into the propofol group (Group P), the ciprofol group (Group C), and the remimazolam group (Group R). The primary outcome measure was the arrhythmia inducibility, while the secondary outcome measures encompassed ablation success, extubation time, bispectral index (BIS) value, peri - operative relevant parameters, and the incidence of postoperative nausea and vomiting.
Results: No significant difference was observed in the arrhythmia inducibility among the three groups (97.40% vs 95.35% vs 94.34%) (P> 0.05). The secondary outcome measures in the three groups, including ablation success (P > 0.05), isoprenaline use (P > 0.05), recurrence (P > 0.05) and operation time (P > 0.05), were similar. Additionally, there was no significant difference in the incidence rates of nausea and vomiting. Excluding the baseline BIS, the Bispectral Index values of Group R were significantly higher than those of Group P and Group C at the same time point (P< 0.05). Moreover, the extubation time in Group R was shorter than that in Group P and Group C.
Conclusion: The effects of ciprofol and remimazolam on arrhythmia inducibility in pediatric supraventricular tachycardia were comparable to those of propofol. Both ciprofol and remimazolam are appropriate for radiofrequency ablation of supraventricular tachycardia in pediatric patients.
Keywords: arrhythmia inducibility, ciprofol, pediatric, radiofrequency ablation, remimazolam, supraventricular tachycardia