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已发表论文
MASP-1 联合四种血栓分子标志物对重症感染患者弥散性血管内凝血预测价值的研究
Authors Chang P, Sun M, Song H, Yang S, Wang Z, Chen L, Wang X
Received 27 May 2025
Accepted for publication 16 October 2025
Published 27 October 2025 Volume 2025:18 Pages 5567—5576
DOI https://doi.org/10.2147/IDR.S543075
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Oliver Planz
Pengfei Chang,1,* Mengxiong Sun,2,* Huitao Song,3 Shuai Yang,2 Ze Wang,1 Lishaui Chen,1 Xunbo Wang4
1Department of Blood Transfusion, Zhangjiakou First Hospital, Zhangjiakou, Hebei Province, 075000, People’s Republic of China; 2Laboratory Department, The First Hospital of Zhangjiakou City, Zhangjiakou, Hebei Province, 075000, People’s Republic of China; 3Department of Neurology and Internal Medicine I, Zhangjiakou First Hospital, Zhangjiakou, Hebei Province, 075000, People’s Republic of China; 4Department of Respiratory Intensive Care Medicine, The First Hospital of Zhangjiakou City, Zhangjiakou, Hebei Province, 075000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xunbo Wang, Email qxb4270@163.com
Objective: To investigate the predictive value of mannose-binding lectin-associated serine protease-1 (MASP-1) combined with four thrombotic molecular markers [thrombin-antithrombin complex (TAT), thrombomodulin (TM), plasmin-α 2-plasmin inhibitor complex (PIC), and tissue-type plasminogen activator inhibitor complex (t-PAIC)] for disseminated intravascular coagulation (DIC) in patients with severe infection.
Methods: Clinical data of 114 patients with severe infection admitted between January and December 2024 were retrospectively analyzed. Patients were divided into DIC (n=25) and non-DIC (n=89) groups per ISTH criteria. Serum MASP-1 (ELISA) and TAT, TM, PIC, t-PAIC (chemiluminescent immunoassay) levels were compared. Pearson correlation assessed relationships between MASP-1 and thrombotic markers. ROC curves evaluated diagnostic performance.
Results: The expression levels of MASP-1, TAT, TM, PIC, and t-PAIC in Group A (with DIC) were significantly higher than those in Group B (without DIC) (P< 0.05). Pearson correlation analysis showed that MASP-1 levels in patients with severe infection and DIC were positively correlated with TAT, TM, PIC, and t-PAIC levels (P< 0.05). ROC curves showed that the area under the curve (AUC) for MASP-1, TAT, TM, PIC, t-PAIC, combined detection of thrombotic molecular markers, and MASP-1 combined with thrombotic molecular markers were 0.714, 0.739, 0.692, 0.684, 0.776, and 0.835, respectively. The diagnostic efficacy of MASP-1 combined with thrombotic molecular markers was superior to MASP-1, TAT, TM, PIC, t-PAIC alone or thrombotic molecular markers combined alone (Z MASP-1+thrombotic markers combined-MASP-1, TAT, TM, PIC, t-PAIC and thrombotic markers combined = 3.637, 3.152, 4.126, 3.974, 4.383, and 2.975, P< 0.05).
Conclusion: This retrospective study suggests that MASP-1 correlates with thrombotic marker expression in severe infection. The combination of MASP-1 and thrombotic markers shows promise for improving early DIC diagnosis, but its clinical utility warrants confirmation by larger, prospective studies.
Keywords: MASP-1, thrombotic molecular markers, severe infection, disseminated intravascular coagulation, predictive value
1Department of Blood Transfusion, Zhangjiakou First Hospital, Zhangjiakou, Hebei Province, 075000, People’s Republic of China; 2Laboratory Department, The First Hospital of Zhangjiakou City, Zhangjiakou, Hebei Province, 075000, People’s Republic of China; 3Department of Neurology and Internal Medicine I, Zhangjiakou First Hospital, Zhangjiakou, Hebei Province, 075000, People’s Republic of China; 4Department of Respiratory Intensive Care Medicine, The First Hospital of Zhangjiakou City, Zhangjiakou, Hebei Province, 075000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xunbo Wang, Email qxb4270@163.com
Objective: To investigate the predictive value of mannose-binding lectin-associated serine protease-1 (MASP-1) combined with four thrombotic molecular markers [thrombin-antithrombin complex (TAT), thrombomodulin (TM), plasmin-α 2-plasmin inhibitor complex (PIC), and tissue-type plasminogen activator inhibitor complex (t-PAIC)] for disseminated intravascular coagulation (DIC) in patients with severe infection.
Methods: Clinical data of 114 patients with severe infection admitted between January and December 2024 were retrospectively analyzed. Patients were divided into DIC (n=25) and non-DIC (n=89) groups per ISTH criteria. Serum MASP-1 (ELISA) and TAT, TM, PIC, t-PAIC (chemiluminescent immunoassay) levels were compared. Pearson correlation assessed relationships between MASP-1 and thrombotic markers. ROC curves evaluated diagnostic performance.
Results: The expression levels of MASP-1, TAT, TM, PIC, and t-PAIC in Group A (with DIC) were significantly higher than those in Group B (without DIC) (P< 0.05). Pearson correlation analysis showed that MASP-1 levels in patients with severe infection and DIC were positively correlated with TAT, TM, PIC, and t-PAIC levels (P< 0.05). ROC curves showed that the area under the curve (AUC) for MASP-1, TAT, TM, PIC, t-PAIC, combined detection of thrombotic molecular markers, and MASP-1 combined with thrombotic molecular markers were 0.714, 0.739, 0.692, 0.684, 0.776, and 0.835, respectively. The diagnostic efficacy of MASP-1 combined with thrombotic molecular markers was superior to MASP-1, TAT, TM, PIC, t-PAIC alone or thrombotic molecular markers combined alone (Z MASP-1+thrombotic markers combined-MASP-1, TAT, TM, PIC, t-PAIC and thrombotic markers combined = 3.637, 3.152, 4.126, 3.974, 4.383, and 2.975, P< 0.05).
Conclusion: This retrospective study suggests that MASP-1 correlates with thrombotic marker expression in severe infection. The combination of MASP-1 and thrombotic markers shows promise for improving early DIC diagnosis, but its clinical utility warrants confirmation by larger, prospective studies.
Keywords: MASP-1, thrombotic molecular markers, severe infection, disseminated intravascular coagulation, predictive value