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已发表论文
子痫前期患者剖宫产术中严格血压管理目标下苯肾上腺素和去甲肾上腺素输注 ED90 值的确定：一项随机序贯分配研究
Authors Ma Y, Ma R, Shi Y, Qin R, Chen Y
Received 9 June 2025
Accepted for publication 26 October 2025
Published 1 November 2025 Volume 2025:19 Pages 9751—9757
DOI https://doi.org/10.2147/DDDT.S545813
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Leonidas Panos
Yueji Ma,* Rong Ma,* Yongqiang Shi, Rui Qin, Yi Chen
Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yi Chen, Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China, Email czzyxgp@163.com
Background: The consensus recommends maintaining the patient’s systolic blood pressure at or above 90% of the baseline value, and highlights the use of vasopressors as the primary strategy for preventing and managing hypotension during cesarean section. This study was aimed to determine the ED90 of prophylactic infusions of norepinephrine and phenylephrine in preeclamptic patients under strict blood pressure management target (maintaining ≥ 90% of the baseline value).
Methods: 60 preeclamptic patients were randomly assigned to either the norepinephrine or the phenylephrine group. The initial patients received an infusion of norepinephrine at 0.05 μg/kg/min or phenylephrine at 0.5 μg/kg/min. For subsequent patients, infusion rates were adjusted in increments or decrements of 0.01 or 0.1 μg/kg/min, respectively, to achieve strict blood pressure management targets before delivery. Secondary outcomes included patients’ adverse events, umbilical artery blood gas analysis, and newborns’ Apgar scores.
Results: The isotonic regression analysis revealed that the ED90 values of norepinephrine and phenylephrine infusions required to maintain a strict blood pressure management targets were 0.076 μg/kg/min (95% CI, 0.070– 0.080) and 0.900 μg/kg/min (95% CI, 0.850– 0.950), respectively. The secondary outcomes between groups were comparable.
Conclusion: Under strict blood pressure management target in preeclamptic patients undergoing cesarean section, the ED90 values for norepinephrine and phenylephrine infusions are 0.076 μg/kg/min and 0.900 μg/kg/min, respectively.
Trial Registration: This study was registered at ClinicalTrials.gov on November 28, 2023 (No. NCT06158022).
Keywords: Preeclampsia, cesarean section, strict blood pressure management target, norepinephrine, phenylephrine
Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yi Chen, Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China, Email czzyxgp@163.com
Background: The consensus recommends maintaining the patient’s systolic blood pressure at or above 90% of the baseline value, and highlights the use of vasopressors as the primary strategy for preventing and managing hypotension during cesarean section. This study was aimed to determine the ED90 of prophylactic infusions of norepinephrine and phenylephrine in preeclamptic patients under strict blood pressure management target (maintaining ≥ 90% of the baseline value).
Methods: 60 preeclamptic patients were randomly assigned to either the norepinephrine or the phenylephrine group. The initial patients received an infusion of norepinephrine at 0.05 μg/kg/min or phenylephrine at 0.5 μg/kg/min. For subsequent patients, infusion rates were adjusted in increments or decrements of 0.01 or 0.1 μg/kg/min, respectively, to achieve strict blood pressure management targets before delivery. Secondary outcomes included patients’ adverse events, umbilical artery blood gas analysis, and newborns’ Apgar scores.
Results: The isotonic regression analysis revealed that the ED90 values of norepinephrine and phenylephrine infusions required to maintain a strict blood pressure management targets were 0.076 μg/kg/min (95% CI, 0.070– 0.080) and 0.900 μg/kg/min (95% CI, 0.850– 0.950), respectively. The secondary outcomes between groups were comparable.
Conclusion: Under strict blood pressure management target in preeclamptic patients undergoing cesarean section, the ED90 values for norepinephrine and phenylephrine infusions are 0.076 μg/kg/min and 0.900 μg/kg/min, respectively.
Trial Registration: This study was registered at ClinicalTrials.gov on November 28, 2023 (No. NCT06158022).
Keywords: Preeclampsia, cesarean section, strict blood pressure management target, norepinephrine, phenylephrine