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已发表论文
胃癌中糖酵解调控的研究进展：关键基因与酶
Authors Chen Z, Li J, Ju H, Yang M, Zhao T
Received 8 July 2025
Accepted for publication 22 October 2025
Published 31 October 2025 Volume 2025:18 Pages 6595—6609
DOI https://doi.org/10.2147/IJGM.S552315
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Ching-Hsien Chen
Zihao Chen,1,* Jiangyu Li,2,* Hongping Ju,2 Man Yang,2 Ting Zhao3
1Department of Surgical Oncology, The First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China; 2School of Medicine, Kunming University, Kunming, People’s Republic of China; 3Department of Clinical Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ting Zhao, Department of Clinical Pharmacy, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, People’s Republic of China, Email zhaoting@kmmu.edu.cn
Abstract: Gastric cancer (GC) is a malignant tumor with extremely high morbidity and mortality. The incidence of GC in China is second only to that of lung cancer, seriously threatening human health and safety. Glycolysis is one of the important ways for cells to obtain energy and most tumor cells also rely on aerobic glycolysis, which plays a key role in the occurrence and development of GC. This article aims to systematically summarize the effects of key glycolytic enzymes and their upstream regulatory genes on GC, to provide a basis for revealing the pathogenesis of GC, and to evaluate potential therapeutic targets for GC.
Keywords: gastric cancer, glycolysis, gene regulation, enzyme regulation
1Department of Surgical Oncology, The First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China; 2School of Medicine, Kunming University, Kunming, People’s Republic of China; 3Department of Clinical Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ting Zhao, Department of Clinical Pharmacy, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, People’s Republic of China, Email zhaoting@kmmu.edu.cn
Abstract: Gastric cancer (GC) is a malignant tumor with extremely high morbidity and mortality. The incidence of GC in China is second only to that of lung cancer, seriously threatening human health and safety. Glycolysis is one of the important ways for cells to obtain energy and most tumor cells also rely on aerobic glycolysis, which plays a key role in the occurrence and development of GC. This article aims to systematically summarize the effects of key glycolytic enzymes and their upstream regulatory genes on GC, to provide a basis for revealing the pathogenesis of GC, and to evaluate potential therapeutic targets for GC.
Keywords: gastric cancer, glycolysis, gene regulation, enzyme regulation