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已发表论文
肉瘤中的细胞外囊泡：对肿瘤进展和治疗的影响
Authors Wang Y , Gao S , Zhang G, Xiao W, Xu B , Li W
Received 31 July 2025
Accepted for publication 17 October 2025
Published 14 November 2025 Volume 2025:20 Pages 13759—13779
DOI https://doi.org/10.2147/IJN.S557436
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Kamakhya Misra
Yue Wang,1,2,* Shaozhi Gao,3,* Geng Zhang,3 Wei Xiao,3 Baoyiyu Xu,3 Wengang Li3
1Central Laboratory, Affiliated Hospital of Putian University, School of Basic Medicine, Putian University, Putian, Fujian Province, 351100, People’s Republic of China; 2Key Laboratory of Translational Tumor Medicine in Fujian Province, Putian University, Putian, Fujian Province, 351100, People’s Republic of China; 3Cancer Research Center, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian Province, 361005, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wengang Li, Email lwgang@xmu.edu.cn
Abstract: Sarcoma, a heterogeneous group of malignancies arising from mesenchymal tissues, poses significant clinical challenges due to its aggressive behavior, early metastasis, and resistance to conventional therapies. Recent advancements highlight the pivotal role of extracellular vesicles (EVs)—nanoscale particles secreted by tumor and stromal cells—in modulating sarcoma progression through intercellular communication within the tumor microenvironment. This review comprehensively examines the multifaceted functions of EVs in sarcoma pathogenesis, focusing on their subtype-specific mechanisms (eg, osteosarcoma, liposarcoma) in promoting epithelial-mesenchymal transition (EMT), angiogenesis, and immune evasion. Additionally, we discuss the emerging potential of EVs as non-invasive biomarkers for early diagnosis and prognosis, as well as their engineered applications in targeted drug delivery and immunotherapy. By integrating cutting-edge research, this article underscores the translational value of EVs in overcoming current therapeutic limitations and provides a roadmap for future investigations into EV-based precision strategies for sarcoma management.
Keywords: extracellular vesicles, sarcoma, tumor microenvironment, biomarkers, therapy
1Central Laboratory, Affiliated Hospital of Putian University, School of Basic Medicine, Putian University, Putian, Fujian Province, 351100, People’s Republic of China; 2Key Laboratory of Translational Tumor Medicine in Fujian Province, Putian University, Putian, Fujian Province, 351100, People’s Republic of China; 3Cancer Research Center, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian Province, 361005, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wengang Li, Email lwgang@xmu.edu.cn
Abstract: Sarcoma, a heterogeneous group of malignancies arising from mesenchymal tissues, poses significant clinical challenges due to its aggressive behavior, early metastasis, and resistance to conventional therapies. Recent advancements highlight the pivotal role of extracellular vesicles (EVs)—nanoscale particles secreted by tumor and stromal cells—in modulating sarcoma progression through intercellular communication within the tumor microenvironment. This review comprehensively examines the multifaceted functions of EVs in sarcoma pathogenesis, focusing on their subtype-specific mechanisms (eg, osteosarcoma, liposarcoma) in promoting epithelial-mesenchymal transition (EMT), angiogenesis, and immune evasion. Additionally, we discuss the emerging potential of EVs as non-invasive biomarkers for early diagnosis and prognosis, as well as their engineered applications in targeted drug delivery and immunotherapy. By integrating cutting-edge research, this article underscores the translational value of EVs in overcoming current therapeutic limitations and provides a roadmap for future investigations into EV-based precision strategies for sarcoma management.
Keywords: extracellular vesicles, sarcoma, tumor microenvironment, biomarkers, therapy