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已发表论文
火针疗法联合盐酸多西环素治疗中重度寻常痤疮的疗效：一项随机对照试验
Authors Zhu T, Li JZ, Sun SY, Ji YF, Ji LX
Received 5 August 2025
Accepted for publication 7 November 2025
Published 13 November 2025 Volume 2025:18 Pages 7471—7484
DOI https://doi.org/10.2147/JMDH.S558510
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Veronica Swallow
Tao Zhu,1,* Jin-Zhen Li,2,* Shi-Yue Sun,3 Yu-Fang Ji,4 Lai-Xi Ji4
1School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Department of Traditional Chinese Medicine, Fujian Maternity and Child Health Hospital, Fuzhou, People’s Republic of China; 3Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 4School of Acu-Mox and Tuina, Shanxi University of Chinese Medicine, Jinzhong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lai-Xi Ji, School of Acu-Mox and Tuina, Shanxi University of Chinese Medicine, Jinzhong, People’s Republic of China, Email jilaixi1964@163.com
Objective: Fire needle therapy has shown promise in treating acne vulgaris (AV), improving facial lesions and patient quality of life. This study aims to investigate the effects of combining fire needle therapy with doxycycline hydrochloride tablets (DHT) on the Global Acne Grading System (GAGS), the échelle d’évaluation clinique des cicatrices d’acné (ECCA) grading scale, the Dermatology Life Quality Index (DLQI), and the serum levels of inflammatory factors interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in patients with moderate-to-severe AV.
Methods: 70 patients with moderate-to-severe AV were randomly assigned to the control group (n=35) to receive oral DHT treatment once a day and the intervention group (n=35) to be treated with fire needle therapy on the basis of DHT once a week. The total treatment duration for both groups was 8 weeks. Therapeutic efficacy was evaluated at the 4-week and 8-week marks. The primary outcome measure evaluated was the GAGS score. The secondary outcome measures included the ECCA score, the DLQI score, and the serum levels of the inflammatory factors IL-17, TNF-α, and IL-6.
Results: Compared to baseline data, both groups exhibited marked improvements in skin lesions at both the 4-week and 8-week treatment marks. Significant reductions were observed in the GAGS, ECCA, and DLQI scores, as well as in the serum levels of the inflammatory factors IL-17, TNF-α, and IL-6. Notably, the intervention group demonstrated significantly greater improvements than the control group at both the 4-week and 8-week assessments.
Conclusion: An 8-week regimen of fire needle therapy combined with DHT improved lesion severity, scar symptoms, quality of life, and serum inflammatory cytokine levels in patients with moderate-to-severe AV compared to DHT monotherapy.
Keywords: needle therapy, doxycycline, acne vulgaris, clinical trail, skin lesions
1School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Department of Traditional Chinese Medicine, Fujian Maternity and Child Health Hospital, Fuzhou, People’s Republic of China; 3Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 4School of Acu-Mox and Tuina, Shanxi University of Chinese Medicine, Jinzhong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lai-Xi Ji, School of Acu-Mox and Tuina, Shanxi University of Chinese Medicine, Jinzhong, People’s Republic of China, Email jilaixi1964@163.com
Objective: Fire needle therapy has shown promise in treating acne vulgaris (AV), improving facial lesions and patient quality of life. This study aims to investigate the effects of combining fire needle therapy with doxycycline hydrochloride tablets (DHT) on the Global Acne Grading System (GAGS), the échelle d’évaluation clinique des cicatrices d’acné (ECCA) grading scale, the Dermatology Life Quality Index (DLQI), and the serum levels of inflammatory factors interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in patients with moderate-to-severe AV.
Methods: 70 patients with moderate-to-severe AV were randomly assigned to the control group (n=35) to receive oral DHT treatment once a day and the intervention group (n=35) to be treated with fire needle therapy on the basis of DHT once a week. The total treatment duration for both groups was 8 weeks. Therapeutic efficacy was evaluated at the 4-week and 8-week marks. The primary outcome measure evaluated was the GAGS score. The secondary outcome measures included the ECCA score, the DLQI score, and the serum levels of the inflammatory factors IL-17, TNF-α, and IL-6.
Results: Compared to baseline data, both groups exhibited marked improvements in skin lesions at both the 4-week and 8-week treatment marks. Significant reductions were observed in the GAGS, ECCA, and DLQI scores, as well as in the serum levels of the inflammatory factors IL-17, TNF-α, and IL-6. Notably, the intervention group demonstrated significantly greater improvements than the control group at both the 4-week and 8-week assessments.
Conclusion: An 8-week regimen of fire needle therapy combined with DHT improved lesion severity, scar symptoms, quality of life, and serum inflammatory cytokine levels in patients with moderate-to-severe AV compared to DHT monotherapy.
Keywords: needle therapy, doxycycline, acne vulgaris, clinical trail, skin lesions