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已发表论文
妊娠期糖尿病患者血清 Tsukushi 水平升高及其与糖脂代谢的关系
Authors Wu X, Jia J, Deng X , Ma X , Yuan G, Yang L, Li H
Received 5 March 2025
Accepted for publication 1 November 2025
Published 12 November 2025 Volume 2025:18 Pages 4167—4176
DOI https://doi.org/10.2147/DMSO.S524997
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Ernesto Maddaloni
Xiangjie Wu,1 Jue Jia,1 Xia Deng,1 Xiaoyan Ma,2 Guoyue Yuan,1 Ling Yang,1 Haoxiang Li1
1Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2Department of Obstetrics, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China
Correspondence: Haoxiang Li, Email 1311533044@qq.com Ling Yang, Email yangling1970@163.com
Objective: Tsukushi (TSK) is a recently identified hepatic factor that has gained prominence for its distinctive function in glycolipid metabolism and energy homeostasis. However, the role of TSK in gestational diabetes mellitus (GDM) remains largely unexplored. In this study, we conducted a pioneering investigation by determining serum TSK levels in patients with GDM and examining the correlation between these levels and various metabolic parameters in gestational diabetes patients.
Methods: A total of 176 pregnant women (mean age 29.5 ± 3.2 years) were recruited from September 2023 to December 2024. Serum TSK levels and clinical markers related to glycolipid metabolism were measured at 24– 28 weeks of gestation. All subjects underwent an oral glucose tolerance test (OGTT).
Results: Serum TSK was significantly higher in patients with GDM than in the normal glucose tolerance group [0.60(0.47,0.73 vs 0.52(0.42,0.67) ng/mL; P < 0.05]. Correlation analysis showed that TSK was significantly and positively correlated with diastolic blood pressure (DBP), alanine aminotransferase (ALT), direct bilirubin (Dbil), free triiodothyronine (FT3), 1-h post-OGTT glucose (1hPG), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC). Logistic regression analysis showed that Logistic regression analysis showed that higher TSK levels were independently associated with increased odds of GDM.
Conclusion: TSK levels were higher in GDM than in NGT (P=0.013), and higher TSK tertiles were independently associated with increased odds of GDM (Model 3 OR=2.883, 95% CI 1.173– 7.084; P=0.021). After FDR correction, only the association with total cholesterol remained significant (FDR-adjusted P=0.023).
Keywords: Tsukushi, gestational diabetes mellitus, pregnancy, insulin resistance
1Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2Department of Obstetrics, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China
Correspondence: Haoxiang Li, Email 1311533044@qq.com Ling Yang, Email yangling1970@163.com
Objective: Tsukushi (TSK) is a recently identified hepatic factor that has gained prominence for its distinctive function in glycolipid metabolism and energy homeostasis. However, the role of TSK in gestational diabetes mellitus (GDM) remains largely unexplored. In this study, we conducted a pioneering investigation by determining serum TSK levels in patients with GDM and examining the correlation between these levels and various metabolic parameters in gestational diabetes patients.
Methods: A total of 176 pregnant women (mean age 29.5 ± 3.2 years) were recruited from September 2023 to December 2024. Serum TSK levels and clinical markers related to glycolipid metabolism were measured at 24– 28 weeks of gestation. All subjects underwent an oral glucose tolerance test (OGTT).
Results: Serum TSK was significantly higher in patients with GDM than in the normal glucose tolerance group [0.60(0.47,0.73 vs 0.52(0.42,0.67) ng/mL; P < 0.05]. Correlation analysis showed that TSK was significantly and positively correlated with diastolic blood pressure (DBP), alanine aminotransferase (ALT), direct bilirubin (Dbil), free triiodothyronine (FT3), 1-h post-OGTT glucose (1hPG), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC). Logistic regression analysis showed that Logistic regression analysis showed that higher TSK levels were independently associated with increased odds of GDM.
Conclusion: TSK levels were higher in GDM than in NGT (P=0.013), and higher TSK tertiles were independently associated with increased odds of GDM (Model 3 OR=2.883, 95% CI 1.173– 7.084; P=0.021). After FDR correction, only the association with total cholesterol remained significant (FDR-adjusted P=0.023).
Keywords: Tsukushi, gestational diabetes mellitus, pregnancy, insulin resistance