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已发表论文
富血小板血浆在慢性肌肉骨骼疼痛中的生物学机制与临床挑战：从标准化制备到多组学指导的精准治疗
Authors Zhou H, Huang Q, Chen Y, Wang J, Jiang H
Received 12 June 2025
Accepted for publication 27 October 2025
Published 7 November 2025 Volume 2025:18 Pages 5931—5939
DOI https://doi.org/10.2147/JPR.S546655
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Michael A Ueberall
Haizhou Zhou,1 Qianjie Huang,2 Yichao Chen,1 Jianmin Wang,1 Hui Jiang2
1Department of Painology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 201700, People’s Republic of China; 2Department of Anesthesiology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 201700, People’s Republic of China
Correspondence: Hui Jiang, Department of Anesthesiology, Qingpu Branch of Zhongshan Hospital, Fudan University, No. 1158 Gongyuan East Road, Shanghai, 201700, People’s Republic of China, Email jianghui20230609@163.com
Background: Chronic musculoskeletal pain (CMP) affects over 1 billion people globally. Platelet-rich plasma (PRP) therapy has emerged as a promising regenerative approach.
Methods: This review synthesizes current literature on PRP’s biological mechanisms, preparation techniques, clinical efficacy, and ethical challenges, with a focus on multi-omics integration for personalized therapy.
Results: PRP promotes tissue repair through growth factor release and immunomodulation, but clinical translation is hampered by preparation variability, lack of predictive biomarkers, and ethical concerns. Multi-omics approaches (genomics, proteomics, metabolomics) offer potential for efficacy prediction and treatment personalization.
Conclusion: Standardization of PRP preparation and rigorous long-term trials are urgently needed. Multi-omics-guided strategies may enhance precision in PRP therapy for CMP.
Keywords: platelet-rich plasma, chronic musculoskeletal pain, tissue regeneration, immunomodulation, multi-omics, precision medicine
1Department of Painology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 201700, People’s Republic of China; 2Department of Anesthesiology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 201700, People’s Republic of China
Correspondence: Hui Jiang, Department of Anesthesiology, Qingpu Branch of Zhongshan Hospital, Fudan University, No. 1158 Gongyuan East Road, Shanghai, 201700, People’s Republic of China, Email jianghui20230609@163.com
Background: Chronic musculoskeletal pain (CMP) affects over 1 billion people globally. Platelet-rich plasma (PRP) therapy has emerged as a promising regenerative approach.
Methods: This review synthesizes current literature on PRP’s biological mechanisms, preparation techniques, clinical efficacy, and ethical challenges, with a focus on multi-omics integration for personalized therapy.
Results: PRP promotes tissue repair through growth factor release and immunomodulation, but clinical translation is hampered by preparation variability, lack of predictive biomarkers, and ethical concerns. Multi-omics approaches (genomics, proteomics, metabolomics) offer potential for efficacy prediction and treatment personalization.
Conclusion: Standardization of PRP preparation and rigorous long-term trials are urgently needed. Multi-omics-guided strategies may enhance precision in PRP therapy for CMP.
Keywords: platelet-rich plasma, chronic musculoskeletal pain, tissue regeneration, immunomodulation, multi-omics, precision medicine