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已发表论文
靶向细菌诱导炎症性疾病中的PANoptosis：机制与治疗策略
Authors Wang T, Lu Y, Zhang X , Yu F
Received 3 September 2025
Accepted for publication 17 November 2025
Published 27 November 2025 Volume 2025:18 Pages 16713—16728
DOI https://doi.org/10.2147/JIR.S563801
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Anh Ngo
摘要：泛凋亡（PANoptosis）是一种新型细胞死亡方式，包括了坏死性凋亡、凋亡、焦亡三种程序性细胞死亡及其之间的相互作用，由泛凋亡复合物（PANoptosome）复合物介导调控。本综述聚焦细菌感染引发的PANoptosis，系统阐述了不同细菌毒力因子激活的差异化通路，并分析了其在炎症性疾病中的作用。此外，文章还总结了细菌性炎症中与PANoptosis相关的潜在治疗策略，为开发新型抗炎药物提供理论依据。了解细菌诱导的PANoptosis机制，将为细菌感染相关炎症性疾病的精准治疗开辟新途径。