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已发表论文
中性粒细胞胞外陷阱在脓毒症及脓毒症相关器官功能障碍中的作用
Authors Yan W, Xu X, Li X, Ma Y, Guo L, Yang J, Jin Z, Zhang J, Li T
Received 24 September 2025
Accepted for publication 15 November 2025
Published 27 November 2025 Volume 2025:14 Pages 1373—1393
DOI https://doi.org/10.2147/ITT.S569962
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Michael Shurin
Wenbo Yan,1,2,* Xiyuan Xu,2,* Xiaojuan Li,1 Yushu Ma,1 Lining Guo,3,4 Jingping Yang,2 Zhipeng Jin,1 Jie Zhang,3– 5 Tiewei Li1
1Department of Clinical Laboratory, Zhengzhou Key Laboratory of Children’s Infection and Immunity, Henan Children’s Hospital, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Inner Mongolia Baogang Hospital, Baotou, Inner Mongolia, People’s Republic of China; 3Department of Otorhinolaryngology Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, People’s Republic of China; 4Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery, Beijing, People’s Republic of China; 5Department of Otorhinolaryngology Head and Neck Surgery, Henan Children’s Hospital, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jie Zhang, Email stzhangj@263.net Tiewei Li, Email litieweind@163.com
Abstract: Sepsis is a systemic inflammatory response triggered by infection, which can result in multiple organ dysfunctions, including disseminated intravascular coagulation (DIC) and acute lung injury (ALI), ultimately leading to patient mortality. The pathophysiology of sepsis is intricate, involving excessive immune activation, cytokine storms, endothelial damage, and microcirculatory dysfunction. Dysregulated host responses frequently give rise to severe complications, markedly elevating mortality rates. Neutrophil extracellular traps (NETs) are web-like structures consisting of DNA, histones, and granular proteins, released by neutrophils upon activation. Ongoing research into NETs has uncovered their significant pathophysiological roles in clinical conditions, including sepsis. This review outlines the mechanisms of NET formation, release, classification, detection methods, and relevant biomarkers. Additionally, it delves into the signaling pathways involved in NET generation, their pathophysiological implications in sepsis and its complications, and evaluates their potential utility in clinical laboratory diagnostics.
Keywords: sepsis, neutrophil extracellular trap, mechanism, biomarker, detection techniques
1Department of Clinical Laboratory, Zhengzhou Key Laboratory of Children’s Infection and Immunity, Henan Children’s Hospital, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Inner Mongolia Baogang Hospital, Baotou, Inner Mongolia, People’s Republic of China; 3Department of Otorhinolaryngology Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, People’s Republic of China; 4Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery, Beijing, People’s Republic of China; 5Department of Otorhinolaryngology Head and Neck Surgery, Henan Children’s Hospital, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jie Zhang, Email stzhangj@263.net Tiewei Li, Email litieweind@163.com
Abstract: Sepsis is a systemic inflammatory response triggered by infection, which can result in multiple organ dysfunctions, including disseminated intravascular coagulation (DIC) and acute lung injury (ALI), ultimately leading to patient mortality. The pathophysiology of sepsis is intricate, involving excessive immune activation, cytokine storms, endothelial damage, and microcirculatory dysfunction. Dysregulated host responses frequently give rise to severe complications, markedly elevating mortality rates. Neutrophil extracellular traps (NETs) are web-like structures consisting of DNA, histones, and granular proteins, released by neutrophils upon activation. Ongoing research into NETs has uncovered their significant pathophysiological roles in clinical conditions, including sepsis. This review outlines the mechanisms of NET formation, release, classification, detection methods, and relevant biomarkers. Additionally, it delves into the signaling pathways involved in NET generation, their pathophysiological implications in sepsis and its complications, and evaluates their potential utility in clinical laboratory diagnostics.
Keywords: sepsis, neutrophil extracellular trap, mechanism, biomarker, detection techniques