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已发表论文
衰老与肠纤维化：机制、影响及治疗策略
Authors Shi Y, Zheng H, Zhu X , Lv J, Zhou M, Zhang S
Received 25 May 2025
Accepted for publication 13 November 2025
Published 26 November 2025 Volume 2025:20 Pages 2177—2194
DOI https://doi.org/10.2147/CIA.S542671
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Nandu Goswami
Yujie Shi,1,* Han Zheng,1,* Xiaxin Zhu,1 Jianyu Lv,2 Mi Zhou,1 Shuo Zhang1
1Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Japan
*These authors contributed equally to this work
Correspondence: Shuo Zhang, The Second Affiliated Hospital of Zhejiang Chinese Medical University, No. 318 Chaowang Road, Gongshu District, Hangzhou, 310005, People’s Republic of China, Tel +86-13957192066, Email zhangshuotcm@126.com
Abstract: With the global aging population, the impact of aging on various organ systems is becoming increasingly significant. The gastrointestinal tract, a key site of immune activity and microbial colonization, undergoes functional decline that is closely associated with a range of intestinal and systemic diseases. While aging-related fibrosis has been extensively studied in organs such as the lungs, liver, heart, and kidneys, its role in intestinal fibrosis remains underexplored. This review discusses mechanisms by which aging may promote or increase the risk of intestinal fibrosis, including immunosenescence, cellular senescence, gut microbiota dysbiosis, and dysregulated growth factor signaling. Additionally, both traditional and emerging therapeutic strategies are summarized to guide future interventions.
Keywords: immunosenescence, cellular senescence, gut microbiota, TGF-β signaling pathway
1Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Japan
*These authors contributed equally to this work
Correspondence: Shuo Zhang, The Second Affiliated Hospital of Zhejiang Chinese Medical University, No. 318 Chaowang Road, Gongshu District, Hangzhou, 310005, People’s Republic of China, Tel +86-13957192066, Email zhangshuotcm@126.com
Abstract: With the global aging population, the impact of aging on various organ systems is becoming increasingly significant. The gastrointestinal tract, a key site of immune activity and microbial colonization, undergoes functional decline that is closely associated with a range of intestinal and systemic diseases. While aging-related fibrosis has been extensively studied in organs such as the lungs, liver, heart, and kidneys, its role in intestinal fibrosis remains underexplored. This review discusses mechanisms by which aging may promote or increase the risk of intestinal fibrosis, including immunosenescence, cellular senescence, gut microbiota dysbiosis, and dysregulated growth factor signaling. Additionally, both traditional and emerging therapeutic strategies are summarized to guide future interventions.
Keywords: immunosenescence, cellular senescence, gut microbiota, TGF-β signaling pathway