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已发表论文
一例转移性原发性胃黑色素瘤致死病例：诊断难题与治疗困境
Authors Zhu X, Ma R, Zheng Q, Si X, Yang G
Received 24 July 2025
Accepted for publication 6 November 2025
Published 26 November 2025 Volume 2025:17 Pages 2923—2929
DOI https://doi.org/10.2147/CMAR.S555895
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Seema Singh
Xiaoyun Zhu,1 Ruchao Ma,2 Qi Zheng,3 Xiujing Si,1 Gang Yang1
1Department of Gastroenterology, Gansu Provincial Hospital, Lanzhou, 730000, People’s Republic of China; 2Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, 730000, People’s Republic of China; 3Department of Respiratory, Gansu Provincial Hospital, Lanzhou, 730000, People’s Republic of China
Correspondence: Gang Yang, Email xiaohuakeyg@163.com
Background: Primary gastric malignant melanoma (PGMM) is an exceedingly rare non-epithelial tumor. Only a limited number of cases have been documented, posing significant diagnostic and therapeutic challenges.
Case Presentation: A 75-year-old man presented with cough and sputum. Computed tomography (CT) suggested a malignant tumor with multiorgan metastasis. Gastroscopy revealed multiple polypoid lesions, and histopathology confirmed melanoma. After multidisciplinary discussion, primary gastric melanoma was diagnosed. Despite aggressive treatment, the disease progressed rapidly, and the patient died six months after diagnosis.
Conclusion: This case highlights the importance of early endoscopy in patients with metastatic tumors of unknown origin. Although outcomes remain poor, this report contributes to the understanding of PGMM diagnosis and management.
Keywords: primary gastric malignant melanoma, PGMM, diagnosis, treatment
1Department of Gastroenterology, Gansu Provincial Hospital, Lanzhou, 730000, People’s Republic of China; 2Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, 730000, People’s Republic of China; 3Department of Respiratory, Gansu Provincial Hospital, Lanzhou, 730000, People’s Republic of China
Correspondence: Gang Yang, Email xiaohuakeyg@163.com
Background: Primary gastric malignant melanoma (PGMM) is an exceedingly rare non-epithelial tumor. Only a limited number of cases have been documented, posing significant diagnostic and therapeutic challenges.
Case Presentation: A 75-year-old man presented with cough and sputum. Computed tomography (CT) suggested a malignant tumor with multiorgan metastasis. Gastroscopy revealed multiple polypoid lesions, and histopathology confirmed melanoma. After multidisciplinary discussion, primary gastric melanoma was diagnosed. Despite aggressive treatment, the disease progressed rapidly, and the patient died six months after diagnosis.
Conclusion: This case highlights the importance of early endoscopy in patients with metastatic tumors of unknown origin. Although outcomes remain poor, this report contributes to the understanding of PGMM diagnosis and management.
Keywords: primary gastric malignant melanoma, PGMM, diagnosis, treatment