111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
针刺治疗颈痛的有效性：系统评价、荟萃分析及试验序贯分析
Authors Xie CR, Zhang ZY , Tao QF, Luo XD, Fu QX , Gao L , Wang T, Ouyang X, Yan Q, Sun MS, Wang X, Liang FR , Zheng H, Zhao L
Received 5 August 2025
Accepted for publication 4 November 2025
Published 25 November 2025 Volume 2025:18 Pages 6297—6316
DOI https://doi.org/10.2147/JPR.S558059
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Houman Danesh
Chao-Rong Xie,1,* Zhi-Yang Zhang,1,* Qing-Feng Tao,1,* Xiang-Dong Luo,2 Qi-Xuan Fu,1 Lei Gao,1 Tong Wang,1 Xu Ouyang,1 Qin-Yi Yan,1 Ming-Sheng Sun,1 Xiao Wang,1 Fan-Rong Liang,1 Hui Zheng,1 Ling Zhao1,3
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Department of Neurology, Sichuan Provincial People’s Hospital, Chengdu, Sichuan, People’s Republic of China; 3Department of Acupuncture and Tuina, Pidu Hospital of Traditional Chinese Medicine (The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, Sichuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ling Zhao, Chengdu University of Traditional Chinese Medicine, No. 1166 Liutai Avenue, Wenjiang District, Chengdu, 611137, People’s Republic of China, Email zhaoling@cdutcm.edu.cn
Purpose and Objectives: Acupuncture is widely utilized intervention for neck pain. Previous research has indicated that acupuncture effectively reduces pain intensity of neck pain. However, its validity remains inconclusive due to repeated significance testing. We aimed to examine the efficacy and safety of acupuncture for neck pain through meta-analysis and trial sequential analysis (TSA).
Methods: We searched the OVID Medline, Embase, and Cochrane Library from inception to October 30, 2024. Randomized controlled trials (RCTs) comparing acupuncture with inert treatment, manual therapy, or other active treatments for neck pain in adults were included.
Results: Twenty-six trials involving 3520 participants were included. Thirteen (50%) trials were at a low risk of bias. Acupuncture treatment demonstrated significantly greater reductions in pain intensity (mean difference [MD] ‒1.26, 95% confidence interval [CI] ‒1.77 to ‒0.75, P < 0.001) and pain perception (MD ‒3.46, 95% CI ‒5.71 to ‒1.21, P = 0.003) compared with inert treatment. The TSA revealed that the cumulative Z-curves for both analyses intersected the TSA cut-off in favor of acupuncture, with the total sample size exceeding the required information size (RIS). Additionally, acupuncture was superior to inert treatment in reducing functional disability after treatment (MD ‒6.52, 95% CI ‒9.8 to ‒3.2, P < 0.001), with cumulative sample size reaching RIS. Acupuncture also showed significant improvements in quality of life. The cumulative z-curve intersects with the TSA cut-off, which is beneficial to acupuncture.
Conclusion: In conclusion, despite the very low to moderate quality of evidence and high heterogeneity that weaken the pooled estimates, our analysis suggests acupuncture might be a safe and effectiveness therapy for neck pain, a finding corroborated by TSA. These results position acupuncture as a potential treatment option, particularly for patients with an inadequate response to conventional therapies. Future high-quality trials are unequivocally needed to strengthen this evidence.
Keywords: acupuncture, neck pain, meta-analysis, trial sequential analysis, systematic review
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Department of Neurology, Sichuan Provincial People’s Hospital, Chengdu, Sichuan, People’s Republic of China; 3Department of Acupuncture and Tuina, Pidu Hospital of Traditional Chinese Medicine (The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, Sichuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ling Zhao, Chengdu University of Traditional Chinese Medicine, No. 1166 Liutai Avenue, Wenjiang District, Chengdu, 611137, People’s Republic of China, Email zhaoling@cdutcm.edu.cn
Purpose and Objectives: Acupuncture is widely utilized intervention for neck pain. Previous research has indicated that acupuncture effectively reduces pain intensity of neck pain. However, its validity remains inconclusive due to repeated significance testing. We aimed to examine the efficacy and safety of acupuncture for neck pain through meta-analysis and trial sequential analysis (TSA).
Methods: We searched the OVID Medline, Embase, and Cochrane Library from inception to October 30, 2024. Randomized controlled trials (RCTs) comparing acupuncture with inert treatment, manual therapy, or other active treatments for neck pain in adults were included.
Results: Twenty-six trials involving 3520 participants were included. Thirteen (50%) trials were at a low risk of bias. Acupuncture treatment demonstrated significantly greater reductions in pain intensity (mean difference [MD] ‒1.26, 95% confidence interval [CI] ‒1.77 to ‒0.75, P < 0.001) and pain perception (MD ‒3.46, 95% CI ‒5.71 to ‒1.21, P = 0.003) compared with inert treatment. The TSA revealed that the cumulative Z-curves for both analyses intersected the TSA cut-off in favor of acupuncture, with the total sample size exceeding the required information size (RIS). Additionally, acupuncture was superior to inert treatment in reducing functional disability after treatment (MD ‒6.52, 95% CI ‒9.8 to ‒3.2, P < 0.001), with cumulative sample size reaching RIS. Acupuncture also showed significant improvements in quality of life. The cumulative z-curve intersects with the TSA cut-off, which is beneficial to acupuncture.
Conclusion: In conclusion, despite the very low to moderate quality of evidence and high heterogeneity that weaken the pooled estimates, our analysis suggests acupuncture might be a safe and effectiveness therapy for neck pain, a finding corroborated by TSA. These results position acupuncture as a potential treatment option, particularly for patients with an inadequate response to conventional therapies. Future high-quality trials are unequivocally needed to strengthen this evidence.
Keywords: acupuncture, neck pain, meta-analysis, trial sequential analysis, systematic review