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已发表论文
利用多种纳米粒子的智能纳米医学系统在骨肉瘤治疗中的应用：综述
Authors Cai J, Yang H, He Z, Wu C
Received 15 August 2025
Accepted for publication 14 November 2025
Published 25 November 2025 Volume 2025:20 Pages 14115—14130
DOI https://doi.org/10.2147/IJN.S560865
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. RDK Misra
Jie Cai,1 Hulin Yang,1 Zongxian He,1 Chenghu Wu2
1Department of Orthopedics, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 311200, People’s Republic of China; 2Department of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325035, People’s Republic of China
Correspondence: Chenghu Wu, Email wuchenghu010@163.com
Abstract: Osteosarcoma and other solid tumor therapies remain urgent clinical challenges. Currently, treatment mainly relies on surgical resection. However, surgery often requires extensive removal of bone and surrounding tissues, which can easily lead to impaired limb function, affect patients’ immune and metabolic functions, and increase the risk of recurrence. Smart nanomedicine offers new hope for the treatment of solid tumors. Nanoparticles can enable targeted drug delivery and personalized treatment, reduce damage to normal tissues, and help prevent dysfunction and disability. Postoperative adjuvant nanomedicines can help eliminate residual tumor cells, lower the recurrence rate, control distant metastasis, and improve survival rates. Additionally, nanoparticle-based immunotherapy has shown promising prospects. By integrating artificial intelligence and big data platforms, the development of smart nanomedicine systems can become more efficient, reliable, and tailored to the specific needs of osteosarcoma therapy. However, there are still biosafety, ethical, and regulatory challenges in clinical translation. In the future, it is necessary to further optimize the targeting and biocompatibility of nanocarriers, strengthen research on tumor metabolism, and improve regulatory systems to promote the clinical application and commercial development of multifunctional nanoparticles.
Keywords: nanoparticles, drug delivery, immune regulation, metabolic regulation, artificial intelligence, nanomedicine
1Department of Orthopedics, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 311200, People’s Republic of China; 2Department of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325035, People’s Republic of China
Correspondence: Chenghu Wu, Email wuchenghu010@163.com
Abstract: Osteosarcoma and other solid tumor therapies remain urgent clinical challenges. Currently, treatment mainly relies on surgical resection. However, surgery often requires extensive removal of bone and surrounding tissues, which can easily lead to impaired limb function, affect patients’ immune and metabolic functions, and increase the risk of recurrence. Smart nanomedicine offers new hope for the treatment of solid tumors. Nanoparticles can enable targeted drug delivery and personalized treatment, reduce damage to normal tissues, and help prevent dysfunction and disability. Postoperative adjuvant nanomedicines can help eliminate residual tumor cells, lower the recurrence rate, control distant metastasis, and improve survival rates. Additionally, nanoparticle-based immunotherapy has shown promising prospects. By integrating artificial intelligence and big data platforms, the development of smart nanomedicine systems can become more efficient, reliable, and tailored to the specific needs of osteosarcoma therapy. However, there are still biosafety, ethical, and regulatory challenges in clinical translation. In the future, it is necessary to further optimize the targeting and biocompatibility of nanocarriers, strengthen research on tumor metabolism, and improve regulatory systems to promote the clinical application and commercial development of multifunctional nanoparticles.
Keywords: nanoparticles, drug delivery, immune regulation, metabolic regulation, artificial intelligence, nanomedicine