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已发表论文
糖尿病足溃疡的先进自然疗法及给药策略：综述简报
Received 2 August 2025
Accepted for publication 14 November 2025
Published 25 November 2025 Volume 2025:19 Pages 10449—10472
DOI https://doi.org/10.2147/DDDT.S557827
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Anastasios Lymperopoulos
Qi Liu,1 Xinxin Yu2
1Department of Peripheral Vascular II, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 2Department of Peripheral Vascular, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang, 150036, People’s Republic of China
Correspondence: Xinxin Yu, Department of Peripheral Vascular, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang, 150036, People’s Republic of China, Email yxx199261@163.com
Abstract: Diabetic foot ulcers (DFUs) are a severe complication of diabetes mellitus with complex pathophysiology. Conventional therapies often lead to poor healing and high recurrence. This mini-review highlights the promise of advanced natural therapeutics and delivery strategies for DFU management. We focus on bioactive natural compounds, such as ginsenosides, astragalus polysaccharides, and resveratrol, that target critical processes like hyperglycemia, vascular impairment, and oxidative stress by modulating key signaling pathways. To improve bioavailability, innovative delivery systems including nanotechnology and nitric oxide-releasing platforms have been developed, enabling sustained release and enhanced healing. Clinical evidence shows promising results, such as shortened healing time and improved ulcer closure rates, supports the translational potential of standardized natural formulations. Moving forward, priorities should focus on standardizing natural formulations, optimizing delivery, and conducting rigorous clinical trials. With continued innovation, natural therapeutics hold significant potential to improve wound healing, reduce amputations, and enhance the quality of life for DFU patients.
Keywords: diabetic foot ulcers, natural therapeutics, bioactive compounds, wound healing, nanotechnology
1Department of Peripheral Vascular II, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 2Department of Peripheral Vascular, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang, 150036, People’s Republic of China
Correspondence: Xinxin Yu, Department of Peripheral Vascular, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang, 150036, People’s Republic of China, Email yxx199261@163.com
Abstract: Diabetic foot ulcers (DFUs) are a severe complication of diabetes mellitus with complex pathophysiology. Conventional therapies often lead to poor healing and high recurrence. This mini-review highlights the promise of advanced natural therapeutics and delivery strategies for DFU management. We focus on bioactive natural compounds, such as ginsenosides, astragalus polysaccharides, and resveratrol, that target critical processes like hyperglycemia, vascular impairment, and oxidative stress by modulating key signaling pathways. To improve bioavailability, innovative delivery systems including nanotechnology and nitric oxide-releasing platforms have been developed, enabling sustained release and enhanced healing. Clinical evidence shows promising results, such as shortened healing time and improved ulcer closure rates, supports the translational potential of standardized natural formulations. Moving forward, priorities should focus on standardizing natural formulations, optimizing delivery, and conducting rigorous clinical trials. With continued innovation, natural therapeutics hold significant potential to improve wound healing, reduce amputations, and enhance the quality of life for DFU patients.
Keywords: diabetic foot ulcers, natural therapeutics, bioactive compounds, wound healing, nanotechnology