111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
苦瓜籽：植物化学、药理学、毒理学、炮制、临床应用及质量标志物预测综述
Authors Deng X, Liu Y, Zhu X, Zhu H, Huang C, Hong Y, Wu D, Han Y
Received 20 July 2025
Accepted for publication 30 October 2025
Published 22 November 2025 Volume 2025:19 Pages 10303—10341
DOI https://doi.org/10.2147/DDDT.S555032
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Anastasios Lymperopoulos
Xin Deng,1 Yanmei Liu,1 Xiaoli Zhu,1 Hui Zhu,1 Cheng Huang,1 Yan Hong,1,2 Deling Wu,2 Yanquan Han1– 3
1Grade Three-Level Laboratory of TCM Preparation, State Administration of Traditional Chinese Medicine, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, People’s Republic of China; 2Anhui University of Chinese Medicine, Hefei, Anhui, People’s Republic of China; 3Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Yan Hong, Email hyan2003@163.com Yanquan Han, Email hyquan2003@163.com
Abstract: Momordicae Semen (MS), a traditional Chinese medicine (TCM), is clinically used to disperse stagnation, reduce swelling, detoxify, and treat sores.. However, its therapeutic potential is limited by inherent toxicity and insufficient quality control standards that fail to reflect its therapeutic value. This review comprehensively synthesizes recent advances in MS research, encompassing phytochemistry, pharmacology, toxicology, herbal processing, and clinical applications. Phytochemical studies have identified a diverse range of bioactive compounds in MS, including triterpenoids and saponins, volatile oils, lignans, phenolic acids, flavonoids, steroids, proteins, peptides, and nitrogenous compounds. Pharmacological studies reveal its broad biological activities, such as antitumor, anti-inflammatory, antimicrobial, antiviral, antiulcer, antioxidant, immunomodulatory, hypolipidemic, hypotensive, and neuroprotective activities. Additionally, the applications of MS in TCM formulations and processed products are summarized, and prospects are examined. Furthermore, its potential quality markers (Q-markers) were systematically predicted based on the principles of specificity, measurability, efficacy correlation, traditional property, transfer and traceability, and network pharmacology. Despite these advances, critical challenges remain, including a limited understanding of its toxicological mechanisms, the processing-induced reduction of toxicity, the metabolic pathways of active constituents, and the need for comprehensive quality control standards. Addressing these issues through future research is essential to enhance the clinical utility and therapeutic potential of MS. This review provides a systematic reference and targeted directions for subsequent studies, which is crucial for realizing the safe, effective, and standardized application of MS in clinical practice and pharmaceutical development.
Keywords: Momordicae Semen, pharmacology, phytochemistry, toxicology, clinical application, Q-markers
1Grade Three-Level Laboratory of TCM Preparation, State Administration of Traditional Chinese Medicine, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, People’s Republic of China; 2Anhui University of Chinese Medicine, Hefei, Anhui, People’s Republic of China; 3Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Yan Hong, Email hyan2003@163.com Yanquan Han, Email hyquan2003@163.com
Abstract: Momordicae Semen (MS), a traditional Chinese medicine (TCM), is clinically used to disperse stagnation, reduce swelling, detoxify, and treat sores.. However, its therapeutic potential is limited by inherent toxicity and insufficient quality control standards that fail to reflect its therapeutic value. This review comprehensively synthesizes recent advances in MS research, encompassing phytochemistry, pharmacology, toxicology, herbal processing, and clinical applications. Phytochemical studies have identified a diverse range of bioactive compounds in MS, including triterpenoids and saponins, volatile oils, lignans, phenolic acids, flavonoids, steroids, proteins, peptides, and nitrogenous compounds. Pharmacological studies reveal its broad biological activities, such as antitumor, anti-inflammatory, antimicrobial, antiviral, antiulcer, antioxidant, immunomodulatory, hypolipidemic, hypotensive, and neuroprotective activities. Additionally, the applications of MS in TCM formulations and processed products are summarized, and prospects are examined. Furthermore, its potential quality markers (Q-markers) were systematically predicted based on the principles of specificity, measurability, efficacy correlation, traditional property, transfer and traceability, and network pharmacology. Despite these advances, critical challenges remain, including a limited understanding of its toxicological mechanisms, the processing-induced reduction of toxicity, the metabolic pathways of active constituents, and the need for comprehensive quality control standards. Addressing these issues through future research is essential to enhance the clinical utility and therapeutic potential of MS. This review provides a systematic reference and targeted directions for subsequent studies, which is crucial for realizing the safe, effective, and standardized application of MS in clinical practice and pharmaceutical development.
Keywords: Momordicae Semen, pharmacology, phytochemistry, toxicology, clinical application, Q-markers