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已发表论文
维持性血液透析患者便秘与衰弱之间的关联：一项横断面研究
Authors Wu S , Dong T , Cao P, Hu N , Deng B , Qiao Q
Received 5 July 2025
Accepted for publication 7 November 2025
Published 21 November 2025 Volume 2025:18 Pages 7659—7666
DOI https://doi.org/10.2147/JMDH.S551776
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Charles V Pollack
Sheng Wu, Ting Dong, Peiyang Cao, Nan Hu, Bingqing Deng, Qing Qiao
Department of Nephrology, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, Jiangsu, People’s Republic of China
Correspondence: Qing Qiao, Email qiaoqingsuda@163.com Bingqing Deng, Email bingqing@tongji.edu.cn
Purpose: Among patients undergoing maintenance hemodialysis (MHD), constipation and frailty are not only common but also associated with adverse clinical outcomes. The objective of this study was to investigate the relationship between constipation and frailty in this population.
Patients and Methods: This cross-sectional study included patients receiving MHD three times per week in China from November 2023 to November 2024. Rome IV criteria and Fried Frailty Phenotype scale were applied to evaluate constipation and frailty respectively. Multivariate logistic regression analysis was utilized to analyze the correlation between constipation and frailty.
Results: Among the 207 enrolled MHD patients (mean age 58.6 ± 14.7 years; 78 females; median hemodialysis vintage 38.4 months), 100 (48.3%) were diagnosed with constipation and 63 (30.4%) with frailty. After adjusting for clinical characteristics, constipation was associated with frailty (OR: 7.61, 95% CI: 2.74– 21.13). Among the five frailty components, slow gait speed (OR: 2.90, 95% CI: 1.20– 7.00) and low physical activity (OR: 3.51, 95% CI: 1.15– 10.74) were independently associated with constipation.
Conclusion: Frailty is independently associated with constipation in MHD patients. It is important to highlight the significance of monitoring the frailty among MHD patients with constipation.
Keywords: constipation, frailty, maintenance hemodialysis, prevalence
Department of Nephrology, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, Jiangsu, People’s Republic of China
Correspondence: Qing Qiao, Email qiaoqingsuda@163.com Bingqing Deng, Email bingqing@tongji.edu.cn
Purpose: Among patients undergoing maintenance hemodialysis (MHD), constipation and frailty are not only common but also associated with adverse clinical outcomes. The objective of this study was to investigate the relationship between constipation and frailty in this population.
Patients and Methods: This cross-sectional study included patients receiving MHD three times per week in China from November 2023 to November 2024. Rome IV criteria and Fried Frailty Phenotype scale were applied to evaluate constipation and frailty respectively. Multivariate logistic regression analysis was utilized to analyze the correlation between constipation and frailty.
Results: Among the 207 enrolled MHD patients (mean age 58.6 ± 14.7 years; 78 females; median hemodialysis vintage 38.4 months), 100 (48.3%) were diagnosed with constipation and 63 (30.4%) with frailty. After adjusting for clinical characteristics, constipation was associated with frailty (OR: 7.61, 95% CI: 2.74– 21.13). Among the five frailty components, slow gait speed (OR: 2.90, 95% CI: 1.20– 7.00) and low physical activity (OR: 3.51, 95% CI: 1.15– 10.74) were independently associated with constipation.
Conclusion: Frailty is independently associated with constipation in MHD patients. It is important to highlight the significance of monitoring the frailty among MHD patients with constipation.
Keywords: constipation, frailty, maintenance hemodialysis, prevalence