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已发表论文
髂筋膜间隙阻滞联合脂质体布比卡因对髋部骨折术后恢复质量的影响：一项前瞻性、随机、对照临床研究
Authors Xie Y , Luo Z, Yan Q, Cai J, Zhu B, Zhang G, Wu X, Liao C , Zheng B
Received 8 May 2025
Accepted for publication 4 November 2025
Published 21 November 2025 Volume 2025:19 Pages 10357—10365
DOI https://doi.org/10.2147/DDDT.S539156
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Georgios Panos
Yuting Xie,1,2 Zhiyu Luo,2 Quanxiang Yan,3 Junling Cai,2 Bin Zhu,2 Gan Zhang,2 Xiaojun Wu,2 Caijiao Liao,2 Bin Zheng4,5
1Shenzhen Baoan School of Clinical Medicine, Guangdong Medical University, Shenzhen, Guangdong, People’s Republic of China; 2Department of Anesthesiology, The People’s Hospital of Baoan Shenzhen, Shenzhen, Guangdong, People’s Republic of China; 3Division of Cardiac Arrhythmia, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of China; 4Department of Anesthesiology, Guangzhou First People’s Hospital, Guangdong Medical University, Guangzhou, Guangdong, People’s Republic of China; 5Department of Anesthesiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guandong, People’s Republic of China
Correspondence: Bin Zheng, Department of Anesthesiology, Guangzhou First People’s Hospital, No. 1 Panfu Road, Guangzhou, People’s Republic of China, Email eyzhengbin@scut.edu.cn
Purpose: To investigate the effect of a fascia iliaca compartment block with liposomal bupivacaine on the quality of recovery after hip fracture surgery.
Patients and Methods: Seventy patients who underwent hip fracture surgery were randomized 1:1 to either the liposomal bupivacaine group (LB group) or ropivacaine group (R group). The LB and R groups received 0.333% liposomal bupivacaine and 0.375% ropivacaine, respectively, for fascia iliaca compartment block. The Quality of Recovery-15 (QoR-15) was assessed at 72 hours postoperatively. We performed between-group comparisons of the highest Numerical Rating Scale (NRS) score during activities at 0– 24 hours, 24– 48 hours and 48– 72 hours postoperatively, amount of opioid consumption within 72 hours postoperatively, recovery time for muscle strength grades II and III, postoperative time to first mobilization, postoperative length of hospital stay, incidence of postoperative adverse reactions, and scores for patient satisfaction with pain relief.
Results: Compared to the R group, the LB group had significantly higher QoR-15 scores and lower opioid consumption at 72 hours postoperatively. There was no significant between-group difference in the highest NRS score during activity within 24 hours postoperatively. However, the LB group had lower NRS scores than the R group within the 24– 48 and 48– 72 hours postoperatively. The postoperative time to first mobilization was significantly shorter in the LB group than in the R group. However, there were no significant between-group differences in the recovery time for grade III muscle strength, postoperative length of hospital stay, incidence of adverse reactions, and pain satisfaction scores.
Conclusion: Fascia iliaca compartment block with liposomal bupivacaine can significantly improve the quality of postoperative recovery and reduce opioid consumption in patients undergoing hip fracture surgery.
Keywords: compartment block, postoperative analgesia, quality of recovery
1Shenzhen Baoan School of Clinical Medicine, Guangdong Medical University, Shenzhen, Guangdong, People’s Republic of China; 2Department of Anesthesiology, The People’s Hospital of Baoan Shenzhen, Shenzhen, Guangdong, People’s Republic of China; 3Division of Cardiac Arrhythmia, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of China; 4Department of Anesthesiology, Guangzhou First People’s Hospital, Guangdong Medical University, Guangzhou, Guangdong, People’s Republic of China; 5Department of Anesthesiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guandong, People’s Republic of China
Correspondence: Bin Zheng, Department of Anesthesiology, Guangzhou First People’s Hospital, No. 1 Panfu Road, Guangzhou, People’s Republic of China, Email eyzhengbin@scut.edu.cn
Purpose: To investigate the effect of a fascia iliaca compartment block with liposomal bupivacaine on the quality of recovery after hip fracture surgery.
Patients and Methods: Seventy patients who underwent hip fracture surgery were randomized 1:1 to either the liposomal bupivacaine group (LB group) or ropivacaine group (R group). The LB and R groups received 0.333% liposomal bupivacaine and 0.375% ropivacaine, respectively, for fascia iliaca compartment block. The Quality of Recovery-15 (QoR-15) was assessed at 72 hours postoperatively. We performed between-group comparisons of the highest Numerical Rating Scale (NRS) score during activities at 0– 24 hours, 24– 48 hours and 48– 72 hours postoperatively, amount of opioid consumption within 72 hours postoperatively, recovery time for muscle strength grades II and III, postoperative time to first mobilization, postoperative length of hospital stay, incidence of postoperative adverse reactions, and scores for patient satisfaction with pain relief.
Results: Compared to the R group, the LB group had significantly higher QoR-15 scores and lower opioid consumption at 72 hours postoperatively. There was no significant between-group difference in the highest NRS score during activity within 24 hours postoperatively. However, the LB group had lower NRS scores than the R group within the 24– 48 and 48– 72 hours postoperatively. The postoperative time to first mobilization was significantly shorter in the LB group than in the R group. However, there were no significant between-group differences in the recovery time for grade III muscle strength, postoperative length of hospital stay, incidence of adverse reactions, and pain satisfaction scores.
Conclusion: Fascia iliaca compartment block with liposomal bupivacaine can significantly improve the quality of postoperative recovery and reduce opioid consumption in patients undergoing hip fracture surgery.
Keywords: compartment block, postoperative analgesia, quality of recovery