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已发表论文
间充质干细胞来源的外泌体在抗神经内分泌肿瘤治疗中的机制、挑战及未来展望
Authors Ye Y, Ye Y, Tian M, Zhao Y, Guo Z, Jin C, Duan S, Zheng Y
Received 26 March 2025
Accepted for publication 14 October 2025
Published 4 December 2025 Volume 2025:20 Pages 14481—14497
DOI https://doi.org/10.2147/IJN.S528771
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Krishna Nune
Yihao Ye,1,2,* Yushan Ye,3,* Mei Tian,3– 5 Yitao Zhao,3 Ziwei Guo,2,6 Chenghong Jin,3 Shiwei Duan,3 Yueliang Zheng2
1The Second School of Clinical Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, People’s Republic of China; 2Emergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 314408, People’s Republic of China; 3Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, 310015, People’s Republic of China; 4Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 314408, People’s Republic of China; 5College of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, People’s Republic of China; 6School of Basic Medicine and Forensic Medicine Hangzhou Medical College, Hangzhou, Zhejiang, 310063, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Shiwei Duan, Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, 310015, People’s Republic of China, Email duansw@hzcu.edu.cn Yueliang Zheng, Emergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 314408, People’s Republic of China, Email Zhengyueliang@hmc.edu.cn
Abstract: Neutrophils, a key component of the innate immune system, play a crucial role in immune responses. In 2004, Brinkmann et al identified neutrophil extracellular traps (NETs) as a novel antibacterial mechanism. However, NETs have since been implicated in the pathogenesis of various diseases, including autoimmune disorders, sepsis, and cancer. Consequently, targeting NETs has emerged as a promising therapeutic approach. Mesenchymal stem cells (MSCs) have demonstrated efficacy in modulating NET formation, but MSC-derived exosomes offer distinct advantages over whole MSCs due to their lower immunogenicity, higher biological stability, and ability to deliver bioactive molecules like miRNAs and CD59. These exosomes can block critical signaling pathways involved in NET formation and protect neutrophil mitochondria, inhibiting NET release. Despite challenges such as low yield and targeting efficiency, ongoing research has made significant strides in addressing these issues. This article reviews the current progress in MSC-derived exosome-based anti-NET therapies and discusses potential strategies to enhance their therapeutic application.
Keywords: neutrophils, neutrophil extracellular traps, exosomes, MSC, MSC-exo
1The Second School of Clinical Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, People’s Republic of China; 2Emergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 314408, People’s Republic of China; 3Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, 310015, People’s Republic of China; 4Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 314408, People’s Republic of China; 5College of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, People’s Republic of China; 6School of Basic Medicine and Forensic Medicine Hangzhou Medical College, Hangzhou, Zhejiang, 310063, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Shiwei Duan, Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, 310015, People’s Republic of China, Email duansw@hzcu.edu.cn Yueliang Zheng, Emergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 314408, People’s Republic of China, Email Zhengyueliang@hmc.edu.cn
Abstract: Neutrophils, a key component of the innate immune system, play a crucial role in immune responses. In 2004, Brinkmann et al identified neutrophil extracellular traps (NETs) as a novel antibacterial mechanism. However, NETs have since been implicated in the pathogenesis of various diseases, including autoimmune disorders, sepsis, and cancer. Consequently, targeting NETs has emerged as a promising therapeutic approach. Mesenchymal stem cells (MSCs) have demonstrated efficacy in modulating NET formation, but MSC-derived exosomes offer distinct advantages over whole MSCs due to their lower immunogenicity, higher biological stability, and ability to deliver bioactive molecules like miRNAs and CD59. These exosomes can block critical signaling pathways involved in NET formation and protect neutrophil mitochondria, inhibiting NET release. Despite challenges such as low yield and targeting efficiency, ongoing research has made significant strides in addressing these issues. This article reviews the current progress in MSC-derived exosome-based anti-NET therapies and discusses potential strategies to enhance their therapeutic application.
Keywords: neutrophils, neutrophil extracellular traps, exosomes, MSC, MSC-exo