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已发表论文
基于黏附性水凝胶的外泌体递送在牙周组织再生及炎症减轻中的应用：综述
Authors Chen H, Zhang L, Duan Y, Lan X, Xu H, Wu L
Received 16 August 2025
Accepted for publication 24 October 2025
Published 4 December 2025 Volume 2025:20 Pages 14413—14437
DOI https://doi.org/10.2147/IJN.S561138
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Kamakhya Misra
Hong Chen,1 Lan Zhang,1 Yuyan Duan,1 Xiaofei Lan,2 Haili Xu,3 Liqin Wu3
1Department of Stomatology, Zhejiang Hospital, Hangzhou, Zhejiang, 310013, People’s Republic of China; 2Department of Transfusion Section, Zhejiang Hospital, Hangzhou, Zhejiang, 310013, People’s Republic of China; 3Department of Stomatology, Tongxiang Hospital of Traditional Chinese Medicine, Tongxiang City, Zhejiang, 314500, People’s Republic of China
Correspondence: Liqin Wu, Department of Stomatology, Tongxiang Hospital of Traditional Chinese Medicine, Tongxiang City, Zhejiang, 314500, People’s Republic of China, Email 13857376662@163.com
Abstract: This review highlights the potential of muco-adhesive hydrogel-based exosome delivery vehicles for the regeneration of periodontal tissue and the reduction of inflammation in periodontitis. Exosomes, mainly produced from mesenchymal stem cells (MSCs), represent nano-sized vesicles loaded with bioactive molecules that can stimulate tissue repair and modulate inflammatory pathways. The review provides a thorough view for the synthesis of the in vitro, in vivo and clinical-pilot studies on exosome-loaded muco-adhesive hydrogels, encompassing the physicochemical characterization, exosome delivery and biological efficacies. In vitro studies highlight the regenerative potential of exosomes on periodontal ligament cells and on alveolar bone cells. In vivo animal models have shown significant improvements in tissue regeneration with effective inflammation control. Preliminary clinical pilot studies similarly show promising results for periodontal tissue healing. The use of exons in combination with muco-adhesive hydrogels provides an effective and non-invasive approach for the targeted, prolonged therapeutic delivery for the treatment of periodontal disease. The main conclusion of this review is that exosome loaded muco-adhesive hydrogels represent a promising strategy for developing strategies to treat periodontitis, setting up as its double aims to enhance the regeneration of tissues and reduce inflammation.
Keywords: exosomes, muco-adhesive hydrogels, periodontitis, tissue regeneration, inflammation modulation, drug delivery systems, regenerative medicine
1Department of Stomatology, Zhejiang Hospital, Hangzhou, Zhejiang, 310013, People’s Republic of China; 2Department of Transfusion Section, Zhejiang Hospital, Hangzhou, Zhejiang, 310013, People’s Republic of China; 3Department of Stomatology, Tongxiang Hospital of Traditional Chinese Medicine, Tongxiang City, Zhejiang, 314500, People’s Republic of China
Correspondence: Liqin Wu, Department of Stomatology, Tongxiang Hospital of Traditional Chinese Medicine, Tongxiang City, Zhejiang, 314500, People’s Republic of China, Email 13857376662@163.com
Abstract: This review highlights the potential of muco-adhesive hydrogel-based exosome delivery vehicles for the regeneration of periodontal tissue and the reduction of inflammation in periodontitis. Exosomes, mainly produced from mesenchymal stem cells (MSCs), represent nano-sized vesicles loaded with bioactive molecules that can stimulate tissue repair and modulate inflammatory pathways. The review provides a thorough view for the synthesis of the in vitro, in vivo and clinical-pilot studies on exosome-loaded muco-adhesive hydrogels, encompassing the physicochemical characterization, exosome delivery and biological efficacies. In vitro studies highlight the regenerative potential of exosomes on periodontal ligament cells and on alveolar bone cells. In vivo animal models have shown significant improvements in tissue regeneration with effective inflammation control. Preliminary clinical pilot studies similarly show promising results for periodontal tissue healing. The use of exons in combination with muco-adhesive hydrogels provides an effective and non-invasive approach for the targeted, prolonged therapeutic delivery for the treatment of periodontal disease. The main conclusion of this review is that exosome loaded muco-adhesive hydrogels represent a promising strategy for developing strategies to treat periodontitis, setting up as its double aims to enhance the regeneration of tissues and reduce inflammation.
Keywords: exosomes, muco-adhesive hydrogels, periodontitis, tissue regeneration, inflammation modulation, drug delivery systems, regenerative medicine