111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
多囊卵巢综合征合并遗传性蛋白 C 缺乏症反复流产患者成功妊娠结局
Authors Qiu L, Zhong M, Tu Y, Mo H, Li L
Received 12 July 2025
Accepted for publication 16 November 2025
Published 3 December 2025 Volume 2025:17 Pages 5117—5128
DOI https://doi.org/10.2147/IJWH.S553265
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Matteo Frigerio
Lin Qiu,1– 3 Minglin Zhong,1 Yanping Tu,4 Hui Mo,2,3 Li Li1,3
1Maternal and Child Health Research Institute, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China; 2Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, People’s Republic of China; 3Dr. Mo Hui’s Inheritance Workshop by National Renowned TCM Doctors, Macao, People’s Republic of China; 4Department of Medical Ultrasonics, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China
Correspondence: Hui Mo, Macau University of Science and Technology, H627, Macau University of Science and Technology, Taipa, Macau, Tel +853-8897-2740, Email mohui@ssm.gov.mo Li Li, Maternal and Child Health Research Institute, Guangdong Women and Children Hospital, Maternal and Child Health Research Institute, Guangdong Women and Children Hospital, Guangzhou, 511442, People’s Republic of China, Tel +020-3915-1961, Email lili-1406@163.com
Abstract: On December 28, 2016, a 35-year-old female patient presenting with chest pain and a brief fainting spell was admitted to a hospital in Guangzhou and promptly received thrombectomy and catheter-directed thrombolysis. She had experienced two episodes of explosive thrombosis, with the second occurring in May 2020, triggered by pregnancy. Her diagnoses included polycystic ovary syndrome (PCOS), hereditary Protein C (PC) deficiency resulting from a heterozygous mutation deletion of 572_574 in exon 7, recurrent spontaneous abortion (RSA), as well as PCOS-associated insulin resistance and chronic endometritis. Our regimen comprises dydrogesterone for cycle regulation, rivaroxaban for PC deficiency-related thrombophilia, and metformin, amoxicillin, and omeprazole to manage PCOS-associated insulin resistance and chronic endometritis, with the aim of mitigating their contribution to impaired endometrial receptivity. Following our targeted and persistent treatment, the patient gave birth to a healthy baby in April 2023. It is rare for RSA to be caused by PCOS complicated by hereditary PC deficiency, and there are no international treatment guidelines for such cases. This report adds to the existing body of knowledge regarding the treatment of PCOS complicated by hereditary PC deficiency. For RSA patients, a comprehensive approach considering all contributing factors and individual circumstances is essential. Multi-disciplinary treatment (MDT) is crucial. Moreover, there are currently no international, evidence-based guidelines for the use of combined oral contraceptives (COCs) in PCOS complicated by hereditary thrombophilia, highlighting the urgent need for multicenter clinical studies to establish appropriate management strategies.
Keywords: PCOS, polycystic ovary syndrome, PC deficiency, protein C deficiency, RSA recurrent spontaneous abortion, VT, venous thromboembolism, childbirth
1Maternal and Child Health Research Institute, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China; 2Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, People’s Republic of China; 3Dr. Mo Hui’s Inheritance Workshop by National Renowned TCM Doctors, Macao, People’s Republic of China; 4Department of Medical Ultrasonics, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of China
Correspondence: Hui Mo, Macau University of Science and Technology, H627, Macau University of Science and Technology, Taipa, Macau, Tel +853-8897-2740, Email mohui@ssm.gov.mo Li Li, Maternal and Child Health Research Institute, Guangdong Women and Children Hospital, Maternal and Child Health Research Institute, Guangdong Women and Children Hospital, Guangzhou, 511442, People’s Republic of China, Tel +020-3915-1961, Email lili-1406@163.com
Abstract: On December 28, 2016, a 35-year-old female patient presenting with chest pain and a brief fainting spell was admitted to a hospital in Guangzhou and promptly received thrombectomy and catheter-directed thrombolysis. She had experienced two episodes of explosive thrombosis, with the second occurring in May 2020, triggered by pregnancy. Her diagnoses included polycystic ovary syndrome (PCOS), hereditary Protein C (PC) deficiency resulting from a heterozygous mutation deletion of 572_574 in exon 7, recurrent spontaneous abortion (RSA), as well as PCOS-associated insulin resistance and chronic endometritis. Our regimen comprises dydrogesterone for cycle regulation, rivaroxaban for PC deficiency-related thrombophilia, and metformin, amoxicillin, and omeprazole to manage PCOS-associated insulin resistance and chronic endometritis, with the aim of mitigating their contribution to impaired endometrial receptivity. Following our targeted and persistent treatment, the patient gave birth to a healthy baby in April 2023. It is rare for RSA to be caused by PCOS complicated by hereditary PC deficiency, and there are no international treatment guidelines for such cases. This report adds to the existing body of knowledge regarding the treatment of PCOS complicated by hereditary PC deficiency. For RSA patients, a comprehensive approach considering all contributing factors and individual circumstances is essential. Multi-disciplinary treatment (MDT) is crucial. Moreover, there are currently no international, evidence-based guidelines for the use of combined oral contraceptives (COCs) in PCOS complicated by hereditary thrombophilia, highlighting the urgent need for multicenter clinical studies to establish appropriate management strategies.
Keywords: PCOS, polycystic ovary syndrome, PC deficiency, protein C deficiency, RSA recurrent spontaneous abortion, VT, venous thromboembolism, childbirth