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已发表论文
间充质干细胞来源的细胞外囊泡在阿尔茨海默病中的应用：一种新型无细胞治疗策略及诊断生物标志物
Authors Wang X , Yang F, Chen P, Yang M, Deng Y, Zhan Z
Received 31 July 2025
Accepted for publication 23 November 2025
Published 3 December 2025 Volume 2025:20 Pages 14375—14391
DOI https://doi.org/10.2147/IJN.S556625
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Xing Zhang
Xiaoling Wang,1,2 Fulan Yang,3 Puwen Chen,1 Mei Yang,1 Yuxin Deng,4 Zhao Zhan5
1The First School of Clinical Medicine, Gannan Medical University, Ganzhou, 341000, People’s Republic of China; 2College of Medical Technology, Gannan Medical University, Ganzhou, 341000, People’s Republic of China; 3Department of Breast Surgery, Ganzhou People’s Hospital, Ganzhou, 341000, People’s Republic of China; 4Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, People’s Republic of China; 5Department of Clinical Laboratory, The First Affiliated Hospital of Yangtze University, Jingzhou, 434000, People’s Republic of China
Correspondence: Yuxin Deng, Email dyxgzmu@163.com Zhao Zhan, Email zhanzhaoytz@163.com
Abstract: With the ongoing trend of population aging worldwide, the incidence of Alzheimer’s disease (AD) is steadily increasing. In the absence of effective therapeutic options for atypical forms of AD, reducing its prevalence and improving treatment outcomes have become pressing priorities. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have attracted growing attention as a new cell-free therapeutic approach for AD due to their high stability, low immunogenicity, and minimal tumorigenic risk. This review provides a comprehensive overview of the pathological mechanisms underlying AD, highlights the diagnostic potential of MSC-EVs, and elaborates on their therapeutic advantages and mechanisms of action. Furthermore, it addresses the key challenges and considerations associated with the clinical translation of MSC-EVs.
Keywords: extracellular vesicles, Alzheimer’s disease, mesenchymal stem cell, β-amyloid protein
1The First School of Clinical Medicine, Gannan Medical University, Ganzhou, 341000, People’s Republic of China; 2College of Medical Technology, Gannan Medical University, Ganzhou, 341000, People’s Republic of China; 3Department of Breast Surgery, Ganzhou People’s Hospital, Ganzhou, 341000, People’s Republic of China; 4Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, People’s Republic of China; 5Department of Clinical Laboratory, The First Affiliated Hospital of Yangtze University, Jingzhou, 434000, People’s Republic of China
Correspondence: Yuxin Deng, Email dyxgzmu@163.com Zhao Zhan, Email zhanzhaoytz@163.com
Abstract: With the ongoing trend of population aging worldwide, the incidence of Alzheimer’s disease (AD) is steadily increasing. In the absence of effective therapeutic options for atypical forms of AD, reducing its prevalence and improving treatment outcomes have become pressing priorities. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have attracted growing attention as a new cell-free therapeutic approach for AD due to their high stability, low immunogenicity, and minimal tumorigenic risk. This review provides a comprehensive overview of the pathological mechanisms underlying AD, highlights the diagnostic potential of MSC-EVs, and elaborates on their therapeutic advantages and mechanisms of action. Furthermore, it addresses the key challenges and considerations associated with the clinical translation of MSC-EVs.
Keywords: extracellular vesicles, Alzheimer’s disease, mesenchymal stem cell, β-amyloid protein