111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
二维斑点追踪超声心动图在评估老年高血压性心脏病患者心功能中的诊断价值
Authors Guo JN, Zhou QY, Peng XX, Li X, Yang RX
Received 4 July 2025
Accepted for publication 13 November 2025
Published 3 December 2025 Volume 2025:20 Pages 2377—2387
DOI https://doi.org/10.2147/CIA.S551673
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Nandu Goswami
Jian-Nan Guo,1 Qiu-Yan Zhou,2 Xiao-Xing Peng,3 Xin Li,1 Rui-Xue Yang1
1Department of Electro-Diagnosis, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun City, Jilin Province, 130021, People’s Republic of China; 2Department of Lung Disease, Tumor and Blood Center, Lung Oncology, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun City, Jilin Province, 130021, People’s Republic of China; 3Department of Medical Imaging, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun City, Jilin Province, 130021, People’s Republic of China
Correspondence: Jian-Nan Guo, Department of Electro-diagnosis, Affiliated Hospital of Changchun University of Chinese Medicine, No. 1475 Gongnong Road, Chaoyang District, Changchun City, Jilin Province, 130021, People’s Republic of China, Email GJN18088688611@outlook.com
Background: Hypertensive heart disease (HHD) in older adults is characterized by structural remodeling and subtle functional impairment that may escape conventional echocardiography. This study aimed to determine the diagnostic value of two-dimensional speckle tracking echocardiography (2D-STE)–derived left atrial strain rates for functional assessment in elderly patients with HHD.
Methods: In this retrospective, single-center cohort, 236 patients aged ≥ 65 years were enrolled (January 2023–January 2025): 118 with echocardiographic HHD and 118 age-matched hypertensive controls without structural abnormalities. Transthoracic echocardiography with 2D-STE quantified mean peak left atrial strain rates in late diastole (mSRa), early diastole (mSRe), and systole (mSRs). Elderly HHD patients were stratified by New York Heart Association (NYHA) class. Group comparisons used t-tests, and receiver operating characteristic (ROC) curves with area under the curve (AUC) evaluated discrimination.
Results: Compared with controls, the HHD group had larger left ventricular end-diastolic diameter (LVEDD 60.29 ± 5.26 vs 48.17 ± 5.46 mm; P< 0.001), lower left ventricular ejection fraction (LVEF 51.10 ± 7.25% vs 61.21 ± 4.96%; P< 0.001), and impaired atrial mechanics (mSRa − 2.20 ± 0.27 vs − 2.75 ± 0.30 s−1; P< 0.001; mSRe − 2.29 ± 0.33 vs − 1.90 ± 0.38 s−1; P< 0.001; mSRs 1.34 ± 0.30 vs 2.15 ± 0.31 s−1; P< 0.001). Within HHD, NYHA III–IV showed worse strain than NYHA I–II (eg, mSRa − 1.90 ± 0.26 vs − 2.48 ± 0.23 s−1; P< 0.001). ROC analysis demonstrated excellent discrimination of functional severity: AUC 0.916 for mSRa (cut-off − 2.367 s−1; sensitivity 96.8%; specificity 76.7%), AUC 0.876 for mSRe (− 2.302 s−1; 91.6%; 65.0%), and AUC 0.881 for mSRs (1.361 s−1; 92.5%; 68.7%) (all P< 0.001).
Conclusion: In elderly HHD, 2D-STE–derived atrial strain rates (mSRa, mSRe, mSRs) are significantly impaired, correlate with NYHA class, and provide high diagnostic accuracy for differentiating mild versus severe functional limitation. These indices may serve as sensitive, non-invasive markers to support early detection and clinical stratification in this population. Prospective studies are needed to establish prognostic utility.
Keywords: two-dimensional speckle tracking echocardiography, hypertensive heart disease, atrial strain, mSRa, mSRe, mSRs, elderly patients, ROC analysis
1Department of Electro-Diagnosis, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun City, Jilin Province, 130021, People’s Republic of China; 2Department of Lung Disease, Tumor and Blood Center, Lung Oncology, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun City, Jilin Province, 130021, People’s Republic of China; 3Department of Medical Imaging, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun City, Jilin Province, 130021, People’s Republic of China
Correspondence: Jian-Nan Guo, Department of Electro-diagnosis, Affiliated Hospital of Changchun University of Chinese Medicine, No. 1475 Gongnong Road, Chaoyang District, Changchun City, Jilin Province, 130021, People’s Republic of China, Email GJN18088688611@outlook.com
Background: Hypertensive heart disease (HHD) in older adults is characterized by structural remodeling and subtle functional impairment that may escape conventional echocardiography. This study aimed to determine the diagnostic value of two-dimensional speckle tracking echocardiography (2D-STE)–derived left atrial strain rates for functional assessment in elderly patients with HHD.
Methods: In this retrospective, single-center cohort, 236 patients aged ≥ 65 years were enrolled (January 2023–January 2025): 118 with echocardiographic HHD and 118 age-matched hypertensive controls without structural abnormalities. Transthoracic echocardiography with 2D-STE quantified mean peak left atrial strain rates in late diastole (mSRa), early diastole (mSRe), and systole (mSRs). Elderly HHD patients were stratified by New York Heart Association (NYHA) class. Group comparisons used t-tests, and receiver operating characteristic (ROC) curves with area under the curve (AUC) evaluated discrimination.
Results: Compared with controls, the HHD group had larger left ventricular end-diastolic diameter (LVEDD 60.29 ± 5.26 vs 48.17 ± 5.46 mm; P< 0.001), lower left ventricular ejection fraction (LVEF 51.10 ± 7.25% vs 61.21 ± 4.96%; P< 0.001), and impaired atrial mechanics (mSRa − 2.20 ± 0.27 vs − 2.75 ± 0.30 s−1; P< 0.001; mSRe − 2.29 ± 0.33 vs − 1.90 ± 0.38 s−1; P< 0.001; mSRs 1.34 ± 0.30 vs 2.15 ± 0.31 s−1; P< 0.001). Within HHD, NYHA III–IV showed worse strain than NYHA I–II (eg, mSRa − 1.90 ± 0.26 vs − 2.48 ± 0.23 s−1; P< 0.001). ROC analysis demonstrated excellent discrimination of functional severity: AUC 0.916 for mSRa (cut-off − 2.367 s−1; sensitivity 96.8%; specificity 76.7%), AUC 0.876 for mSRe (− 2.302 s−1; 91.6%; 65.0%), and AUC 0.881 for mSRs (1.361 s−1; 92.5%; 68.7%) (all P< 0.001).
Conclusion: In elderly HHD, 2D-STE–derived atrial strain rates (mSRa, mSRe, mSRs) are significantly impaired, correlate with NYHA class, and provide high diagnostic accuracy for differentiating mild versus severe functional limitation. These indices may serve as sensitive, non-invasive markers to support early detection and clinical stratification in this population. Prospective studies are needed to establish prognostic utility.
Keywords: two-dimensional speckle tracking echocardiography, hypertensive heart disease, atrial strain, mSRa, mSRe, mSRs, elderly patients, ROC analysis