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已发表论文
肾结石与我国老年人群肌肉减少症患病率之间的关联：一项基于倾向评分匹配的横断面研究
Authors Wu C , Li XQ, Lu SS, Shen ZK, Lu X
Received 18 June 2025
Accepted for publication 25 November 2025
Published 2 December 2025 Volume 2025:20 Pages 2353—2362
DOI https://doi.org/10.2147/CIA.S547830
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Zhi-Ying Wu
Cheng Wu,1,* Xiao-Qing Li,1,* Shan-Shan Lu,1,* Zheng-Kai Shen,2 Xiang Lu1
1Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Jiangsu Province Center for Disease Control and Prevention, Nanjing, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiang Lu, Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, People’s Republic of China, Email luxiang66@njmu.edu.cn Zheng-Kai Shen, MPH, Jiangsu Province Center for Disease Control and Prevention, Nanjing, 210009, People’s Republic of China, Email shenzhengkai@jscdc.cn
Background: Sarcopenia is an age-related condition characterized by loss of muscle mass and function. Nephrolithiasis represents a prevalent urological disorder that imposes a substantial burden on healthcare resources. However, the association between sarcopenia and nephrolithiasis remains poorly characterized.
Methods: A total of 2586 older adults were included in this cross-sectional study. We used the univariate and multivariate logistic regression models to assess the relationship between nephrolithiasis and sarcopenia. Additionally, stratified analyses and propensity score matching (PSM) were performed to account for potential confounding factors.
Results: The prevalence of sarcopenia in the present study was 7.2%. In Model 4, which integrated for all relevant covariates, nephrolithiasis was associated with approximately a 190% increased prevalence of sarcopenia compared to non-nephrolithiasis patients (OR: 2.912, 95% CI: 1.708– 4.968, P < 0.001). Following PSM, the results also confirmed the association between nephrolithiasis and sarcopenia (OR: 4.426, 95% CI: 1.547– 12.661, P = 0.006). Notably, this association was more pronounced in subgroups including males (OR: 3.296, 95% CI: 1.436– 7.564, P = 0.005), lower education level (OR: 8.127, 95% CI: 3.057– 21.609, P < 0.001), and diabetes (OR: 6.686, 95% CI: 2.626– 17.027, P < 0.001).
Conclusion: Our findings demonstrate that nephrolithiasis is positively related to the potential risk of sarcopenia in Chinese older adults. This finding indicates that nephrolithiasis may contribute to sarcopenia development, thereby emphasizing that prevention and intervention strategies for sarcopenia should account for the adverse effects of nephrolithiasis.
Keywords: cross-sectional study, nephrolithiasis, older adults, propensity score matching, sarcopenia
1Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Jiangsu Province Center for Disease Control and Prevention, Nanjing, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiang Lu, Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, People’s Republic of China, Email luxiang66@njmu.edu.cn Zheng-Kai Shen, MPH, Jiangsu Province Center for Disease Control and Prevention, Nanjing, 210009, People’s Republic of China, Email shenzhengkai@jscdc.cn
Background: Sarcopenia is an age-related condition characterized by loss of muscle mass and function. Nephrolithiasis represents a prevalent urological disorder that imposes a substantial burden on healthcare resources. However, the association between sarcopenia and nephrolithiasis remains poorly characterized.
Methods: A total of 2586 older adults were included in this cross-sectional study. We used the univariate and multivariate logistic regression models to assess the relationship between nephrolithiasis and sarcopenia. Additionally, stratified analyses and propensity score matching (PSM) were performed to account for potential confounding factors.
Results: The prevalence of sarcopenia in the present study was 7.2%. In Model 4, which integrated for all relevant covariates, nephrolithiasis was associated with approximately a 190% increased prevalence of sarcopenia compared to non-nephrolithiasis patients (OR: 2.912, 95% CI: 1.708– 4.968, P < 0.001). Following PSM, the results also confirmed the association between nephrolithiasis and sarcopenia (OR: 4.426, 95% CI: 1.547– 12.661, P = 0.006). Notably, this association was more pronounced in subgroups including males (OR: 3.296, 95% CI: 1.436– 7.564, P = 0.005), lower education level (OR: 8.127, 95% CI: 3.057– 21.609, P < 0.001), and diabetes (OR: 6.686, 95% CI: 2.626– 17.027, P < 0.001).
Conclusion: Our findings demonstrate that nephrolithiasis is positively related to the potential risk of sarcopenia in Chinese older adults. This finding indicates that nephrolithiasis may contribute to sarcopenia development, thereby emphasizing that prevention and intervention strategies for sarcopenia should account for the adverse effects of nephrolithiasis.
Keywords: cross-sectional study, nephrolithiasis, older adults, propensity score matching, sarcopenia