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已发表论文
残余胆固醇作为高尿酸血症优于低密度脂蛋白胆固醇的标志物：中国西北地区的一项横断面研究
Authors Lu X , Liang H, Zhou X, Wu Y, Sha L, Lei H
Received 14 September 2025
Accepted for publication 10 November 2025
Published 1 December 2025 Volume 2025:18 Pages 4411—4421
DOI https://doi.org/10.2147/DMSO.S563873
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Pablo Corral
Xixuan Lu, Haiyan Liang, Xiaoli Zhou, Yuemei Wu, Liping Sha, Hong Lei
Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China
Correspondence: Xixuan Lu, Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University, No. 804, Shengli South Street, Xingqing District, Yinchuan, Ningxia, 750004, People’s Republic of China, Email xixuan86@163.com; Luxixuan@nyfy.com.cn
Purpose: Hyperuricemia is a precursor to gout and is linked to various metabolic disorders. This study investigated the associations of hyperuricemia with concordant/discordant lipid phenotypes based on low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC).
Methods: We analyzed 8,971 participants from a cluster-stratified random sample across six provinces in Northwest China. They were categorized into four groups by LDL-C and RC levels: NRC+NLDL, NRC+HLDL, HRC+NLDL, and HRC+HLDL. Multivariable logistic regression was used to assess the odds of hyperuricemia across these groups.
Results: Participants in Group NRC+HLDL, Group HRC+NLDL, and Group HRC+HLDL exhibited an increased risk for hyperuricemia by 37%, 96%, and 120%, respectively (OR: 1.37, 95% CI: 1.13– 1.66 for NRC+HLDL; OR: 1.96, 95% CI: 1.57– 2.45 for HRC+NLDL; OR: 2.20, 95% CI: 1.82– 2.65 for HRC+HLDL), relative to Group NRC+NLDL. Subgroup analyses highlighted significant interaction effects based on gender and hypertriglyceridemia, with a more pronounced association observed in female participants. Sensitivity analyses revealed Group HRC+NLDL was most closely related to HUA when stricter LDL-C cut-offs were applied. Body mass index (BMI) and waist circumference (WC) mediated 20.27% and 6.67% of this association, respectively.
Conclusion: RC demonstrated a stronger association with hyperuricemia than LDL-C, partially mediated by BMI and WC. Women exhibited greater susceptibility to RC-related hyperuricemia.
Keywords: remnant cholesterol, low-density lipoprotein cholesterol, hyperuricemia, discordance, concordance
Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China
Correspondence: Xixuan Lu, Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University, No. 804, Shengli South Street, Xingqing District, Yinchuan, Ningxia, 750004, People’s Republic of China, Email xixuan86@163.com; Luxixuan@nyfy.com.cn
Purpose: Hyperuricemia is a precursor to gout and is linked to various metabolic disorders. This study investigated the associations of hyperuricemia with concordant/discordant lipid phenotypes based on low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC).
Methods: We analyzed 8,971 participants from a cluster-stratified random sample across six provinces in Northwest China. They were categorized into four groups by LDL-C and RC levels: NRC+NLDL, NRC+HLDL, HRC+NLDL, and HRC+HLDL. Multivariable logistic regression was used to assess the odds of hyperuricemia across these groups.
Results: Participants in Group NRC+HLDL, Group HRC+NLDL, and Group HRC+HLDL exhibited an increased risk for hyperuricemia by 37%, 96%, and 120%, respectively (OR: 1.37, 95% CI: 1.13– 1.66 for NRC+HLDL; OR: 1.96, 95% CI: 1.57– 2.45 for HRC+NLDL; OR: 2.20, 95% CI: 1.82– 2.65 for HRC+HLDL), relative to Group NRC+NLDL. Subgroup analyses highlighted significant interaction effects based on gender and hypertriglyceridemia, with a more pronounced association observed in female participants. Sensitivity analyses revealed Group HRC+NLDL was most closely related to HUA when stricter LDL-C cut-offs were applied. Body mass index (BMI) and waist circumference (WC) mediated 20.27% and 6.67% of this association, respectively.
Conclusion: RC demonstrated a stronger association with hyperuricemia than LDL-C, partially mediated by BMI and WC. Women exhibited greater susceptibility to RC-related hyperuricemia.
Keywords: remnant cholesterol, low-density lipoprotein cholesterol, hyperuricemia, discordance, concordance