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已发表论文
近二十年来维生素 D 与骨关节炎关联的全球研究现状及趋势的文献计量学与可视化分析
Authors Yang Z, Ong MT , Mak RWF, Ng JP, Meng H, Wang Z
Received 14 July 2025
Accepted for publication 23 November 2025
Published 1 December 2025 Volume 2025:18 Pages 7779—7795
DOI https://doi.org/10.2147/JMDH.S553576
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Pavani Rangachari
Zongyou Yang,1 Michael Tim‐Yun Ong,2,3 Rex Wang-Fung Mak,3 Jonathan Patrick Ng,3 Hongyu Meng,1 Zhihong Wang1
1Department of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, People’s Republic of China; 2Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; 3Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Shatin, Hong Kong
Correspondence: Zhihong Wang, Department of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, People’s Republic of China, 050051, Tel +86 031166776721, Email wzhresearch@163.com Michael Tim‐Yun Ong, Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Email michael.ong@cuhk.edu.hk
Background: Osteoarthritis (OA) is a common degenerative joint disease affecting many individuals worldwide. The relationship between vitamin D and OA has recently attracted attention from researchers, as the available data concerning the influence of vitamin D on OA progression are controversial. Here, we conducted a visualized analysis of the world research trends on vitamin D and OA from 2005 to 2024.
Methods: A search was conducted to identify papers published between 2005 and 2024 in the Web of Science Core Collection (WoSCC) database. A total of 400 publications on vitamin D and OA were included and analyzed using Microsoft Excel, VOSviewer, and CiteSpace. We reported the annual publication trends, leading countries, institutions, and authors. Co-authorship, co-citation, and keyword bursts were analyzed further to determine research foci and evolving trends.
Results: The volume of publications consistently increased, peaking in 2021. The United States was the leading country (70 publications), followed by China (49) and the United Kingdom (). The high centralities of Harvard University and Monash University highlight their strong role in international collaboration. Ding Changhai, Jones Graeme, and Wluka Anita were the most productive authors. “Vitamin D Deficiency” was found to be most influential. Five clusters were identified. Further analysis revealed the current interest in and future research directions related to the roles of vitamin D in OA.
Conclusion: Publication volume on vitamin D and OA increased steadily in the last two decades. Research focus evolved from basic bone metabolism to specific vitamin D metabolites and inflammation mechanisms. Investigations continue into vitamin D’s role in specific OA phenotypes and inflammatory pathways. The underrepresentation of low and middle-income countries represents a critical research gap. Recent research explores vitamin D’s potential for managing OA symptoms, with future work likely focusing on its biochemical and clinical effects in OA treatment.
Keywords: bibliometrics, CiteSpace, VOSviewer, visualization, vitamin D, osteoarthritis
1Department of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, People’s Republic of China; 2Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; 3Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Shatin, Hong Kong
Correspondence: Zhihong Wang, Department of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, People’s Republic of China, 050051, Tel +86 031166776721, Email wzhresearch@163.com Michael Tim‐Yun Ong, Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Email michael.ong@cuhk.edu.hk
Background: Osteoarthritis (OA) is a common degenerative joint disease affecting many individuals worldwide. The relationship between vitamin D and OA has recently attracted attention from researchers, as the available data concerning the influence of vitamin D on OA progression are controversial. Here, we conducted a visualized analysis of the world research trends on vitamin D and OA from 2005 to 2024.
Methods: A search was conducted to identify papers published between 2005 and 2024 in the Web of Science Core Collection (WoSCC) database. A total of 400 publications on vitamin D and OA were included and analyzed using Microsoft Excel, VOSviewer, and CiteSpace. We reported the annual publication trends, leading countries, institutions, and authors. Co-authorship, co-citation, and keyword bursts were analyzed further to determine research foci and evolving trends.
Results: The volume of publications consistently increased, peaking in 2021. The United States was the leading country (70 publications), followed by China (49) and the United Kingdom (). The high centralities of Harvard University and Monash University highlight their strong role in international collaboration. Ding Changhai, Jones Graeme, and Wluka Anita were the most productive authors. “Vitamin D Deficiency” was found to be most influential. Five clusters were identified. Further analysis revealed the current interest in and future research directions related to the roles of vitamin D in OA.
Conclusion: Publication volume on vitamin D and OA increased steadily in the last two decades. Research focus evolved from basic bone metabolism to specific vitamin D metabolites and inflammation mechanisms. Investigations continue into vitamin D’s role in specific OA phenotypes and inflammatory pathways. The underrepresentation of low and middle-income countries represents a critical research gap. Recent research explores vitamin D’s potential for managing OA symptoms, with future work likely focusing on its biochemical and clinical effects in OA treatment.
Keywords: bibliometrics, CiteSpace, VOSviewer, visualization, vitamin D, osteoarthritis