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基于进化理论治疗多线治疗失败的晚期结肠癌肺转移：一例病例报告
Authors Wu X, Xian Q , Ling R, Zhu W
Received 22 August 2025
Accepted for publication 15 November 2025
Published 4 December 2025 Volume 2025:18 Pages 1533—1538
DOI https://doi.org/10.2147/IMCRJ.S560068
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Thomas E Hutson
摘要：结直肠癌是全球第三大常见恶性肿瘤，也是癌症相关死亡的第二大原因。目前，针对晚期结肠癌的三线及以上治疗仍缺乏标准方案。瘤内异质性与肿瘤进化在多种癌症中得到证实，这为探索结直肠癌肺转移的治疗新策略提供了理论依据。本文报告一例晚期结肠癌伴肺转移患者，在经历包括FOLFOX、FOLFIRI联合靶向治疗及免疫联合靶向治疗在内的多线治疗失败后, 从肿瘤进化视角出发，采用针对原发性肺癌的治疗方案处理结直肠癌肺转移灶。结果显示，治疗2周期后患者达到部分缓解，治疗8周期后病情保持稳定，且生活质量良好。本研究提示，从进化角度借鉴原发性肺癌的治疗策略，或可为标准治疗无效的结直肠癌肺转移患者提供新的治疗思路。