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已发表论文
间充质干细胞外泌体在组织工程中的当前应用及未来挑战：文献计量分析
Authors Chen S , Di J, Zhang Z, Guo Z, Tian Z, Qin Y , Long Y, Xu J , Xiang C , Cao F
Received 25 June 2025
Accepted for publication 6 December 2025
Published 11 December 2025 Volume 2025:20 Pages 14885—14910
DOI https://doi.org/10.2147/IJN.S549684
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. RDK Misra
Shuai Chen,1,2,* Jingkai Di,1,2,* Zhibo Zhang,1 Zijian Guo,1,2 Zui Tian,1,2 Yingda Qin,1,2 Yingi Long,1 Jiake Xu,3– 5 Chuan Xiang,1 Fuyang Cao1,2
1Department of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 3Center for AI-Driven Medical Research, Chinese Academy of Sciences, Shenzhen, Guangdong, People’s Republic of China; 4Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen, Guangdong, People’s Republic of China; 5School of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia
*These authors contributed equally to this work
Correspondence: Chuan Xiang, Email chuanxiang@sxmu.edu.cn Fuyang Cao, Email doctorcao1995@163.com
Background: Extracellular vesicles derived from mesenchymal stem cells (MSCs-EVs) are nano-sized vesicles and have become key mediators in tissue engineering and emerging therapeutic agents in regenerative medicine. This study systematically assessed the global research trend of MSCs-EVs for tissue engineering through bibliometric analysis of literature from 2014 to 2024.
Methods: A comprehensive search of Web of Science retrieved 752 eligible articles. We visualized and further analyzed collaboration, co-citation, co-authorship and co-occurrence through VOSviewer and Citespace, focusing on their application and future development trends.
Results: Annual publications increased continuously, with China and the United States accounting for 48.9% and 19.1% of research output, respectively, accompanied by intensive transnational cooperation. China leads in number of publications, number of years, total citations, H index and collaboration. The evolution of research trends confirms that the current field of application has expanded from cellular repair to drug delivery systems and biomaterial integration. Keyword cooccurrence reveals three clusters of research: artificial editing of exosomes (membranes), drug delivery (drugs, nucleic acids), and regeneration mechanisms (bone morphogenesis, angiogenesis regulation). The International Journal of Molecular Science became the most influential journal, and Shanghai Jiaotong University was a leader in institutional productivity.
Conclusion: This study is the first comprehensive quantitative analysis of tissue-engineered EVs and details trends and advances in tissue-engineered EVs research within the field of regenerative medicine. It portrays recent frontiers and hotspots, providing valuable insights for researchers in this particular area of research.
Keywords: extracellular vesicles, exosomes, mesenchymal stem cells, tissue engineering, regenerative medicine, bibliometrics, visualization
1Department of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 3Center for AI-Driven Medical Research, Chinese Academy of Sciences, Shenzhen, Guangdong, People’s Republic of China; 4Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen, Guangdong, People’s Republic of China; 5School of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia
*These authors contributed equally to this work
Correspondence: Chuan Xiang, Email chuanxiang@sxmu.edu.cn Fuyang Cao, Email doctorcao1995@163.com
Background: Extracellular vesicles derived from mesenchymal stem cells (MSCs-EVs) are nano-sized vesicles and have become key mediators in tissue engineering and emerging therapeutic agents in regenerative medicine. This study systematically assessed the global research trend of MSCs-EVs for tissue engineering through bibliometric analysis of literature from 2014 to 2024.
Methods: A comprehensive search of Web of Science retrieved 752 eligible articles. We visualized and further analyzed collaboration, co-citation, co-authorship and co-occurrence through VOSviewer and Citespace, focusing on their application and future development trends.
Results: Annual publications increased continuously, with China and the United States accounting for 48.9% and 19.1% of research output, respectively, accompanied by intensive transnational cooperation. China leads in number of publications, number of years, total citations, H index and collaboration. The evolution of research trends confirms that the current field of application has expanded from cellular repair to drug delivery systems and biomaterial integration. Keyword cooccurrence reveals three clusters of research: artificial editing of exosomes (membranes), drug delivery (drugs, nucleic acids), and regeneration mechanisms (bone morphogenesis, angiogenesis regulation). The International Journal of Molecular Science became the most influential journal, and Shanghai Jiaotong University was a leader in institutional productivity.
Conclusion: This study is the first comprehensive quantitative analysis of tissue-engineered EVs and details trends and advances in tissue-engineered EVs research within the field of regenerative medicine. It portrays recent frontiers and hotspots, providing valuable insights for researchers in this particular area of research.
Keywords: extracellular vesicles, exosomes, mesenchymal stem cells, tissue engineering, regenerative medicine, bibliometrics, visualization