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已发表论文
肿瘤学中表观遗传联合疗法的推进：用于协同疗效和精准调节的多功能纳米药物递送系统
Authors Gao T , Fu S, Quan X, Sun J, Jiang M, Li J
Received 8 September 2025
Accepted for publication 2 December 2025
Published 11 December 2025 Volume 2025:20 Pages 14853—14883
DOI https://doi.org/10.2147/IJN.S566173
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Professor Dong Wang
Tong Gao,1,* Shunli Fu,2,* Xianghua Quan,1 Jialin Sun,1 Man Jiang,1 Jing Li1
1Department of Pharmacy, the Affiliated Hospital of Qingdao University, Qingdao, 266000, People’s Republic of China; 2Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Li, Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People’s Republic of China, Email lijing7112@126.com
Abstract: Epigenetic modifications regulate gene expression at the transcriptional level, contributing to tumorigenesis and progression. While epigenetic-targeted combination therapies have gained prominence in oncology treatment management, their clinical efficacy remains constrained by differences in pharmacokinetics and biodistribution among combined agents. Nano-drug delivery systems (NDDS) demonstrate unique potential through co-delivery of therapeutic agents and optimization of their pharmacokinetic profiles. Furthermore, the development of multifunctional NDDS opens new possibilities for precision modulation in cancer treatment, offering valuable insights for clinical translation. Here, this review first outlined the intervention mechanisms of epigenetic dysregulation and analyzed the applications of epigenetic combination approaches. Subsequently, we highlight the transformative potential of NDDS in epigenetic combination therapy, with particular emphasis on how multifunctional NDDS design enables precise therapeutic regulation. This comprehensive analysis aims to advance the clinical translation of epigenetic-based combination strategies through innovative drug delivery solutions. In the future, with the continuous development of AI-driven NDDS design, biomimetic carriers, and dynamic epigenetic editing tools, it will be possible to overcome the clinical challenges of NDDS, enabling truly personalized cancer treatment.
Keywords: epigenetics, cancer combination therapy, nano-drug delivery systems, multifunctional drug delivery strategy
1Department of Pharmacy, the Affiliated Hospital of Qingdao University, Qingdao, 266000, People’s Republic of China; 2Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Li, Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People’s Republic of China, Email lijing7112@126.com
Abstract: Epigenetic modifications regulate gene expression at the transcriptional level, contributing to tumorigenesis and progression. While epigenetic-targeted combination therapies have gained prominence in oncology treatment management, their clinical efficacy remains constrained by differences in pharmacokinetics and biodistribution among combined agents. Nano-drug delivery systems (NDDS) demonstrate unique potential through co-delivery of therapeutic agents and optimization of their pharmacokinetic profiles. Furthermore, the development of multifunctional NDDS opens new possibilities for precision modulation in cancer treatment, offering valuable insights for clinical translation. Here, this review first outlined the intervention mechanisms of epigenetic dysregulation and analyzed the applications of epigenetic combination approaches. Subsequently, we highlight the transformative potential of NDDS in epigenetic combination therapy, with particular emphasis on how multifunctional NDDS design enables precise therapeutic regulation. This comprehensive analysis aims to advance the clinical translation of epigenetic-based combination strategies through innovative drug delivery solutions. In the future, with the continuous development of AI-driven NDDS design, biomimetic carriers, and dynamic epigenetic editing tools, it will be possible to overcome the clinical challenges of NDDS, enabling truly personalized cancer treatment.
Keywords: epigenetics, cancer combination therapy, nano-drug delivery systems, multifunctional drug delivery strategy