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已发表论文
针对膝关节微环境的药物递送系统：膝骨关节炎治疗的前瞻性策略
Authors Xia Y , Zhou Y, Liang B, Guo Y, Dai R, Ruan Z, Wang W, Zhou X, Li X, Wang T
Received 3 September 2025
Accepted for publication 21 November 2025
Published 11 December 2025 Volume 2025:19 Pages 10909—10935
DOI https://doi.org/10.2147/DDDT.S564907
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Leonidas Panos
Yubo Xia,1,* Yang Zhou,2,3,* Boshen Liang,4,* Ying Guo,1,* Rong Dai,5 Ziliang Ruan,1 Wei Wang,6 Xiaohan Zhou,1 Xiufang Li,5 Tao Wang1
1Third Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, People’s Republic of China; 2First Clinical Medical College,Yunnan University of Chinese Medicine, Kunming, People’s Republic of China; 3Joint Graduate School of Traditional Chinese Medicine of China, Suzhou, People’s Republic of China; 4Guang zhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 5College of Traditional Chinese Materia Medica,Yunnan University of Chinese Medicine, Kunming, People’s Republic of China; 6Department of Cardiology, The Second People’s Hospital of Kunming, Kunming, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiufang Li, College of Traditional Chinese Materia Medica,Yunnan University of Chinese Medicine, Kunming, People’s Republic of China, Tel +86-13908856005, Email sofinelxf@163.com Tao Wang, Third Affiliated Hospital,Yunnan University of Chinese Medicine, Kunming, People’s Republic of China, Tel +86-13648800064, Email 183070775@qq.com
Abstract: Knee osteoarthritis (KOA) is a degenerative condition of the joints marked by the gradual deterioration of cartilage, inflammation, and pain, impacting millions globally. Treatment approaches for KOA encompass both surgical and non-surgical methods aimed at alleviating symptoms and enhancing functionality rather than providing a cure. Recent research into the mechanisms of osteoarthritis (OA) has highlighted the significance of the knee joint’s microenvironment in the success of drug delivery, particularly with intra-articular therapies. A notable approach involves intra-articular (IA) injections, which allow for the targeted administration of medications directly into the joint area. Nevertheless, traditional treatments often fall short in effectiveness due to the limited bioavailability of drugs within the joint, quick clearance rates, and potential systemic side effects. Consequently, innovative drug delivery systems (DDS) that focus on the knee joint’s microenvironment have emerged as a viable method to enhance treatment efficacy and improve patient outcomes. Additionally, drug delivery systems utilizing nanotechnology have shown advantages such as precise targeting, minimized systemic toxicity, and extended therapeutic effects in treating diseases. Gaining insight into these interactions is crucial for developing optimized drug delivery systems that can improve treatment results for individuals with knee disorders. This article examines the latest developments in nanotechnology-based therapies for KOA and explores future directions for enhancing and refining treatment strategies for this condition.
Keywords: knee osteoarthritis, drug delivery systems, nanotechnology, hydrogel, microspheres, exosomes, NF-κB, extracellular matrix degradation
1Third Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, People’s Republic of China; 2First Clinical Medical College,Yunnan University of Chinese Medicine, Kunming, People’s Republic of China; 3Joint Graduate School of Traditional Chinese Medicine of China, Suzhou, People’s Republic of China; 4Guang zhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 5College of Traditional Chinese Materia Medica,Yunnan University of Chinese Medicine, Kunming, People’s Republic of China; 6Department of Cardiology, The Second People’s Hospital of Kunming, Kunming, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiufang Li, College of Traditional Chinese Materia Medica,Yunnan University of Chinese Medicine, Kunming, People’s Republic of China, Tel +86-13908856005, Email sofinelxf@163.com Tao Wang, Third Affiliated Hospital,Yunnan University of Chinese Medicine, Kunming, People’s Republic of China, Tel +86-13648800064, Email 183070775@qq.com
Abstract: Knee osteoarthritis (KOA) is a degenerative condition of the joints marked by the gradual deterioration of cartilage, inflammation, and pain, impacting millions globally. Treatment approaches for KOA encompass both surgical and non-surgical methods aimed at alleviating symptoms and enhancing functionality rather than providing a cure. Recent research into the mechanisms of osteoarthritis (OA) has highlighted the significance of the knee joint’s microenvironment in the success of drug delivery, particularly with intra-articular therapies. A notable approach involves intra-articular (IA) injections, which allow for the targeted administration of medications directly into the joint area. Nevertheless, traditional treatments often fall short in effectiveness due to the limited bioavailability of drugs within the joint, quick clearance rates, and potential systemic side effects. Consequently, innovative drug delivery systems (DDS) that focus on the knee joint’s microenvironment have emerged as a viable method to enhance treatment efficacy and improve patient outcomes. Additionally, drug delivery systems utilizing nanotechnology have shown advantages such as precise targeting, minimized systemic toxicity, and extended therapeutic effects in treating diseases. Gaining insight into these interactions is crucial for developing optimized drug delivery systems that can improve treatment results for individuals with knee disorders. This article examines the latest developments in nanotechnology-based therapies for KOA and explores future directions for enhancing and refining treatment strategies for this condition.
Keywords: knee osteoarthritis, drug delivery systems, nanotechnology, hydrogel, microspheres, exosomes, NF-κB, extracellular matrix degradation