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已发表论文
直肠癌回肠造口术后伤口感染风险因素模型的构建及其与核苷酸结合寡聚化结构域样受体蛋白 3（NLRP3）基因多态性的关系
Authors Li Y, Zhou Y, Wang F, Shi P, Yang J, Zhang B, Shi R, Wei M, Ren H
Received 21 April 2025
Accepted for publication 3 September 2025
Published 11 December 2025 Volume 2025:18 Pages 6521—6534
DOI https://doi.org/10.2147/IDR.S535810
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hazrat Bilal
Yang Li,1,* Yan Zhou,2,* Fanke Wang,2 Piaopiao Shi,2 Jianling Yang,3 Bing Zhang,3 Ruizhe Shi,2 Ming Wei,2 Huan Ren4
1Department of Gynaecology and Obstetrics, The Third Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China; 2Department of Gastrointestinal Disease Diagnosis and Treatment Two Departments, The First Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China; 3Department of General Surgery Ward Two, Chinese People’s Liberation Army Bethune International Peace Hospital, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China; 4Department of Anus and Intestine Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huan Ren, Department of Anus and Intestine Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China, Email renh2024h@163.com Ming Wei, Department of Gastrointestinal Disease Diagnosis and Treatment Two Departments, The First Hospital of Hebei Medical University, No. 215, Heping Road, Xinhua District, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China, Tel +86 0311 66002999, Email weim68m@21cn.com
Objective: To establish a predictive model for wound infection after ileostomy for rectal cancer and its relationship with nucleotide-binding oligomerisation domain-like receptor thermal protein domain-associated protein 3 (NLRP3) gene polymorphism.
Methods: A total of 347 samples were randomly divided into two groups: the model group (n = 260) and the verification group (n = 87). The patients in the model group were further divided into the infection group (n = 96) and the non-infection group (n = 164). Multivariate logistic regression was used to analyse the influencing factors of postoperative infection. The TaqMan probe method was used for genotyping.
Results: The results of multivariate logistic regression analysis showed that age > 65 years, diabetes, operation time > 105 minutes, loop colostomy and abnormal transepidermal water loss (TEWL) were independent risk factors. The risk value of postoperative wound infection predicted by the nomogram model reached 0.93, corresponding to a maximum predicted infection probability of 92.68%. The area under the receiver operating characteristic curve for the nomogram model was 0.869 (P < 0.001) and 0.861 (P < 0.001). The comparison of NLRP3 genotypes between the two groups showed that the proportion of the GG genotype was significantly higher in the infection group than the CC and CG genotypes (51.43% vs 29.90% and 38.98%, respectively). In patients with the GG genotype, the associations between age > 65 years, diabetes and abnormal TEWL with wound infection remained significant (all P < 0.05), indicating that these clinical risk factors are particularly prevalent among GG carriers.
Conclusion: This study identified the independent risk factors for postoperative wound infection. Patients with the G allele have a higher risk of postoperative infection, and NLRP3 gene polymorphism is closely associated with the risk factors included in the model. The association between NLRP3 gene polymorphisms and the risk of postoperative infection provides a new molecular biological indicator for prognostic evaluation.
Keywords: nucleotide, binding oligomerisation domain, like receptor thermal protein domain, associated protein 3, single, nucleotide polymorphism, ileostomy, wound infection
1Department of Gynaecology and Obstetrics, The Third Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China; 2Department of Gastrointestinal Disease Diagnosis and Treatment Two Departments, The First Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China; 3Department of General Surgery Ward Two, Chinese People’s Liberation Army Bethune International Peace Hospital, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China; 4Department of Anus and Intestine Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huan Ren, Department of Anus and Intestine Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China, Email renh2024h@163.com Ming Wei, Department of Gastrointestinal Disease Diagnosis and Treatment Two Departments, The First Hospital of Hebei Medical University, No. 215, Heping Road, Xinhua District, Shijiazhuang City, Hebei Province, 050000, People’s Republic of China, Tel +86 0311 66002999, Email weim68m@21cn.com
Objective: To establish a predictive model for wound infection after ileostomy for rectal cancer and its relationship with nucleotide-binding oligomerisation domain-like receptor thermal protein domain-associated protein 3 (NLRP3) gene polymorphism.
Methods: A total of 347 samples were randomly divided into two groups: the model group (n = 260) and the verification group (n = 87). The patients in the model group were further divided into the infection group (n = 96) and the non-infection group (n = 164). Multivariate logistic regression was used to analyse the influencing factors of postoperative infection. The TaqMan probe method was used for genotyping.
Results: The results of multivariate logistic regression analysis showed that age > 65 years, diabetes, operation time > 105 minutes, loop colostomy and abnormal transepidermal water loss (TEWL) were independent risk factors. The risk value of postoperative wound infection predicted by the nomogram model reached 0.93, corresponding to a maximum predicted infection probability of 92.68%. The area under the receiver operating characteristic curve for the nomogram model was 0.869 (P < 0.001) and 0.861 (P < 0.001). The comparison of NLRP3 genotypes between the two groups showed that the proportion of the GG genotype was significantly higher in the infection group than the CC and CG genotypes (51.43% vs 29.90% and 38.98%, respectively). In patients with the GG genotype, the associations between age > 65 years, diabetes and abnormal TEWL with wound infection remained significant (all P < 0.05), indicating that these clinical risk factors are particularly prevalent among GG carriers.
Conclusion: This study identified the independent risk factors for postoperative wound infection. Patients with the G allele have a higher risk of postoperative infection, and NLRP3 gene polymorphism is closely associated with the risk factors included in the model. The association between NLRP3 gene polymorphisms and the risk of postoperative infection provides a new molecular biological indicator for prognostic evaluation.
Keywords: nucleotide, binding oligomerisation domain, like receptor thermal protein domain, associated protein 3, single, nucleotide polymorphism, ileostomy, wound infection