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已发表论文
妊娠期皮肤黏附物样甜综合征一例
Authors Ruan Z, Yang L , Tu P, Yu D
Received 21 August 2025
Accepted for publication 5 December 2025
Published 10 December 2025 Volume 2025:17 Pages 5355—5360
DOI https://doi.org/10.2147/IJWH.S562354
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Matteo Frigerio
Zhenqiang Ruan,1,* Luan Yang,1,* Ping Tu,2 Debao Yu1
1Department of Dermatology, Jinan Dermatosis Prevention and Control Hospital, Jinan, Shandong, People’s Republic of China; 2Department of Dermatology, Peking University First Hospital, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Debao Yu, Department of Dermatology, Jinan Dermatosis Prevention and Control Hospital, No. 165, Jing San Road, Huaiyin District, Jinan, Shandong, 250021, People’s Republic of China, Email ydb7309@163.com
Abstract: Pregnancy-associated Sweet syndrome (PASS), is a diagnostically challenging entity, especially in atypical presentations. Delayed management may result in significant maternal-fetal risks. We describe a 24-year-old woman with PASS presenting like cutaneous dirt-adherent disease, characterized by abrupt-onset facial erythematous plaques with adherent dirt-like crusts. Histopathology revealed superficial dermal edema and dense perivascular neutrophilic infiltrates without vasculitis. Low-dose systemic corticosteroids (prednisone 20mg/day) achieved rapid resolution, underscoring their efficacy and safety in pregnancy. This case explores the potential pathogenesis of PASS and underscores the necessity for awareness among clinicians about PASS, contributing valuable insights into the diagnosis and management of this rare condition in pregnancy.
Keywords: sweet syndrome, dermatosis neglecta, pregnancy, neutrophilic dermatosis, treatment
1Department of Dermatology, Jinan Dermatosis Prevention and Control Hospital, Jinan, Shandong, People’s Republic of China; 2Department of Dermatology, Peking University First Hospital, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Debao Yu, Department of Dermatology, Jinan Dermatosis Prevention and Control Hospital, No. 165, Jing San Road, Huaiyin District, Jinan, Shandong, 250021, People’s Republic of China, Email ydb7309@163.com
Abstract: Pregnancy-associated Sweet syndrome (PASS), is a diagnostically challenging entity, especially in atypical presentations. Delayed management may result in significant maternal-fetal risks. We describe a 24-year-old woman with PASS presenting like cutaneous dirt-adherent disease, characterized by abrupt-onset facial erythematous plaques with adherent dirt-like crusts. Histopathology revealed superficial dermal edema and dense perivascular neutrophilic infiltrates without vasculitis. Low-dose systemic corticosteroids (prednisone 20mg/day) achieved rapid resolution, underscoring their efficacy and safety in pregnancy. This case explores the potential pathogenesis of PASS and underscores the necessity for awareness among clinicians about PASS, contributing valuable insights into the diagnosis and management of this rare condition in pregnancy.
Keywords: sweet syndrome, dermatosis neglecta, pregnancy, neutrophilic dermatosis, treatment