111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
血小板与血红蛋白比值在预测冠状动脉旁路移植术后主要不良心血管事件中的作用
Authors Chen S , Zhang K, Liu X, Yang Z, Guan X, Zhou X, Xiao J, Li X, Jin J, Ma X , Li Q
Received 21 August 2025
Accepted for publication 29 November 2025
Published 10 December 2025 Volume 2025:21 Pages 1047—1058
DOI https://doi.org/10.2147/VHRM.S562298
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Harry Struijker-Boudier
Shanghao Chen,1– 3,* Kefan Zhang,1,2,* Xuantao Liu,1,2,* Zhihao Yang,1,2,* Xiang Guan,1,2 Xin Zhou,1,2 Junwen Xiao,1,2 Xiaofang Li,1,2 Jing Jin,1,2 Xiaochun Ma,4 Qingguo Li1,2
1Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Artificial Heart Research Institute, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 3Department of Cardiovascular Surgery, Shandong Provincial Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 4Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Qingguo Li, Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanjing Medical University, No. 290 Heyan Road, Nanjing, Jiangsu, 210003, People’s Republic of China, Tel +0086 025 22681, Email liqg@njmu.edu.cn Xiaochun Ma, Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Jinan, Shandong, 250021, People’s Republic of China, Tel +86 531 6877 6353, Email mxcmxc2008@163.com
Purpose: Coronary artery bypass grafting (CABG) is widely recognized as the gold standard treatment for patients with complex coronary artery disease (CAD). The identification of reliable hematologic predictors for major adverse cardiovascular events (MACE) after CABG remains limited. In recent years, the platelet-to-hemoglobin ratio (PHR) has emerged as a promising prognostic marker in various cardiovascular conditions and malignancies. This study investigated the prognostic value of the PHR for predicting in-hospital and short-term adverse outcomes after CABG.
Patients and Methods: This retrospective cohort study included 1672 Chinese patients who underwent isolated CABG surgery between 2015 and 2021. PHR was calculated as platelet count (× 109/L) divided by hemoglobin (g/L). The primary endpoint was 3-point MACE (3P-MACE), including cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke during hospitalization. A predictive nomogram was developed and validated using bootstrap resampling.
Results: In our study, individuals with elevated PHR levels were more likely to experience 3P-MACE and stroke. After propensity matching, the incidence of 3P-MACE was 5.7% in the high PHR group (PHR≥ 1.890) and 1.5% in the low PHR group (P = 0.010). Multivariate analysis identified preoperative PHR (odds ratio: 1.800 [95% CI 1.073– 3.021], P=0.026) as an independent predictor for 3P-MACE post-CABG. A predictive nomogram for 3P-MACE following CABG was successfully developed. The predictive performance of PHR was comparable to NLR and PLR, with an area under the ROC curve (AUC) of 0.595 (95% CI 0.486– 0.691). Combining PHR with nomogram parameters improved AUC to 0.762 (95% CI 0.687– 0.837).
Conclusion: Elevated PHR (≥ 1.890) was independently associated with postoperative 3P-MACE, reflecting the integrated effects of thrombosis and anemia risk. Although PHR demonstrated modest discrimination as a single variable, its integration into a multivariable nomogram improved predictive accuracy. These findings are hypothesis-generating and future multicenter, prospective validation studies are warranted.
Keywords: platelet-to-hemoglobin ratio, predicting, major adverse cardiovascular events, coronary artery bypass, nomograms
1Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Artificial Heart Research Institute, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 3Department of Cardiovascular Surgery, Shandong Provincial Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 4Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Qingguo Li, Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanjing Medical University, No. 290 Heyan Road, Nanjing, Jiangsu, 210003, People’s Republic of China, Tel +0086 025 22681, Email liqg@njmu.edu.cn Xiaochun Ma, Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Jinan, Shandong, 250021, People’s Republic of China, Tel +86 531 6877 6353, Email mxcmxc2008@163.com
Purpose: Coronary artery bypass grafting (CABG) is widely recognized as the gold standard treatment for patients with complex coronary artery disease (CAD). The identification of reliable hematologic predictors for major adverse cardiovascular events (MACE) after CABG remains limited. In recent years, the platelet-to-hemoglobin ratio (PHR) has emerged as a promising prognostic marker in various cardiovascular conditions and malignancies. This study investigated the prognostic value of the PHR for predicting in-hospital and short-term adverse outcomes after CABG.
Patients and Methods: This retrospective cohort study included 1672 Chinese patients who underwent isolated CABG surgery between 2015 and 2021. PHR was calculated as platelet count (× 109/L) divided by hemoglobin (g/L). The primary endpoint was 3-point MACE (3P-MACE), including cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke during hospitalization. A predictive nomogram was developed and validated using bootstrap resampling.
Results: In our study, individuals with elevated PHR levels were more likely to experience 3P-MACE and stroke. After propensity matching, the incidence of 3P-MACE was 5.7% in the high PHR group (PHR≥ 1.890) and 1.5% in the low PHR group (P = 0.010). Multivariate analysis identified preoperative PHR (odds ratio: 1.800 [95% CI 1.073– 3.021], P=0.026) as an independent predictor for 3P-MACE post-CABG. A predictive nomogram for 3P-MACE following CABG was successfully developed. The predictive performance of PHR was comparable to NLR and PLR, with an area under the ROC curve (AUC) of 0.595 (95% CI 0.486– 0.691). Combining PHR with nomogram parameters improved AUC to 0.762 (95% CI 0.687– 0.837).
Conclusion: Elevated PHR (≥ 1.890) was independently associated with postoperative 3P-MACE, reflecting the integrated effects of thrombosis and anemia risk. Although PHR demonstrated modest discrimination as a single variable, its integration into a multivariable nomogram improved predictive accuracy. These findings are hypothesis-generating and future multicenter, prospective validation studies are warranted.
Keywords: platelet-to-hemoglobin ratio, predicting, major adverse cardiovascular events, coronary artery bypass, nomograms