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已发表论文
中性粒细胞/淋巴细胞比值与血小板/淋巴细胞比值作为术前腰椎队列中MRI源性椎体骨质量的辅助标志物
Authors Ma L, Liu Y, Qin Y, Liu Y, Yu H, Ma Z, Nan C
Received 10 July 2025
Accepted for publication 2 December 2025
Published 10 December 2025 Volume 2025:21 Pages 1679—1687
DOI https://doi.org/10.2147/TCRM.S552982
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Garry Walsh
Liang Ma,1 Yuxiu Liu,2 Yazhuo Qin,1 Yong Liu,1 Hetong Yu,1 Zhanbei Ma,1 Chong Nan1
1Department of Orthopedic, Baoding No. 1 Central Hospital, Baoding, Hebei, People’s Republic of China; 2Department of Western Pharmacy, Baoding No. 1 Central Hospital, Baoding, Hebei, People’s Republic of China
Correspondence: Chong Nan, Department of Orthopedic, Baoding No. 1 Central Hospital, Baoding, Hebei, People’s Republic of China, Email md-evan@qq.com
Background: MRI-derived vertebral bone quality (VBQ) rises with marrow fat and denotes poorer bone integrity. We examined whether simple inflammatory ratios—neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR)—relate to VBQ in degenerative lumbar disease.
Methods: We retrospectively studied 200 patients aged ≥ 50 years who underwent surgery between January 2022 and January 2024. VBQ was calculated on mid-sagittal T1-weighted MRI using vertebral and cerebrospinal-fluid regions of interest. Associations were tested with Spearman correlations and multivariable linear regression adjusting for age, sex, smoking, diabetes, and body mass index (BMI).
Results: Among 200 patients (mean age = 64.8 ± 8.7 years), those with higher VBQ values (indicating poorer bone quality) were older and had higher NLR and PLR (all p< 0.001). VBQ showed significant positive correlations with age (ρ = 0.650), NLR (ρ = 0.534), and PLR (ρ = 0.452) (all p< 0.001). In multivariable regression, age, NLR, and PLR remained independently associated with higher VBQ, whereas BMI, sex, smoking, and diabetes were not significant (adjusted R2=0.520; all VIF≤ 2.26). Standardized effect sizes indicated moderate independent contributions (β_std = 0.151 for NLR; β_std = 0.303 for PLR), corresponding to roughly 0.020-unit and 0.075-unit increases in VBQ per 1-unit NLR and 50-unit PLR increments, respectively.
Conclusion: Preoperative NLR and PLR were independently associated with higher MRI-derived VBQ and may aid imaging-based risk stratification; prospective validation with calibrated thresholds is needed.
Keywords: vertebral bone quality, neutrophil-to-lymphocyte, platelet-to-lymphocyte, osteoporosis
1Department of Orthopedic, Baoding No. 1 Central Hospital, Baoding, Hebei, People’s Republic of China; 2Department of Western Pharmacy, Baoding No. 1 Central Hospital, Baoding, Hebei, People’s Republic of China
Correspondence: Chong Nan, Department of Orthopedic, Baoding No. 1 Central Hospital, Baoding, Hebei, People’s Republic of China, Email md-evan@qq.com
Background: MRI-derived vertebral bone quality (VBQ) rises with marrow fat and denotes poorer bone integrity. We examined whether simple inflammatory ratios—neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR)—relate to VBQ in degenerative lumbar disease.
Methods: We retrospectively studied 200 patients aged ≥ 50 years who underwent surgery between January 2022 and January 2024. VBQ was calculated on mid-sagittal T1-weighted MRI using vertebral and cerebrospinal-fluid regions of interest. Associations were tested with Spearman correlations and multivariable linear regression adjusting for age, sex, smoking, diabetes, and body mass index (BMI).
Results: Among 200 patients (mean age = 64.8 ± 8.7 years), those with higher VBQ values (indicating poorer bone quality) were older and had higher NLR and PLR (all p< 0.001). VBQ showed significant positive correlations with age (ρ = 0.650), NLR (ρ = 0.534), and PLR (ρ = 0.452) (all p< 0.001). In multivariable regression, age, NLR, and PLR remained independently associated with higher VBQ, whereas BMI, sex, smoking, and diabetes were not significant (adjusted R2=0.520; all VIF≤ 2.26). Standardized effect sizes indicated moderate independent contributions (β_std = 0.151 for NLR; β_std = 0.303 for PLR), corresponding to roughly 0.020-unit and 0.075-unit increases in VBQ per 1-unit NLR and 50-unit PLR increments, respectively.
Conclusion: Preoperative NLR and PLR were independently associated with higher MRI-derived VBQ and may aid imaging-based risk stratification; prospective validation with calibrated thresholds is needed.
Keywords: vertebral bone quality, neutrophil-to-lymphocyte, platelet-to-lymphocyte, osteoporosis