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已发表论文
负载姜黄素的贻贝黏附蛋白修饰普朗尼克F127胶束的皮肤递送增强及银屑病局部治疗效果研究
Authors Niu J , Yuan M, Wang L, Zhang P, Cui X, Wang J, Liu X
Received 17 September 2025
Accepted for publication 5 December 2025
Published 9 December 2025 Volume 2025:20 Pages 14733—14752
DOI https://doi.org/10.2147/IJN.S563465
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. RDK Misra
Jiangxiu Niu,1,* Ming Yuan,1,* Liye Wang,1 Pei Zhang,2 Xingang Cui,3 Jucai Wang,1 Xianming Liu1
1College of Food and Drug, Luoyang Normal University, Luoyang, Henan, 471934, People’s Republic of China; 2College of Life Science, Luoyang Normal University, Luoyang, Henan, 471934, People’s Republic of China; 3Department of Research and Teaching, Luoyang Maternal and Child Health Hospital, Luoyang, Henan, 471000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Pei Zhang, Email zhangpei8877@126.com Xingang Cui, Email cuixingang5207@163.com
Background: Psoriasis is a long-term inflammatory skin disorder that significantly impacts the physical and psychological well-being of those affected. Curcumin (Cur) is a natural compound that holds promise for the topical management of psoriasis. However, the barrier property of the stratum corneum (SC) and the insufficient retention ability of the drug in the skin have severely restricted the clinical efficacy of Cur. To overcome these limitations, we introduced mussel adhesive protein (MAP) for its superior bioadhesive properties, and developed Cur-loaded MAP modified Pluronic F127 micelles (MAP-F127/Cur) to improve the skin permeation and retention of Cur and enhance the therapeutic effect on psoriasis.
Methods: In this study, MAP-F127 was synthesized via chemical synthesis. MAP-F127/Cur was prepared using the thin-film hydration method, and the physicochemical properties of the formulation were characterized. In addition, porcine skin was employed as an in vitro model to evaluate the skin permeation of the formulation and to elucidate the interaction mechanism between the formulation and the skin. Furthermore, the therapeutic efficacy of the formulation against psoriasis was assessed using an imiquimod-induced psoriasis mouse model.
Results: The prepared MAP-F127/Cur had a regular spherical shape and good dispersion, and could efficiently load Cur in the amorphous form. The skin retention of MAP-F127/Cur was notably elevated in comparison to both the Cur-loaded Pluronic F127 micelles (F127/Cur) and Cur solution (p< 0.01). Studies on the skin permeation mechanism showed that MAP-F127/Cur could break through the restriction of the skin barrier by regulating lipid arrangement and keratin conformation in the SC, forming a long-acting drug reservoir in the epidermal layer. Furthermore, in the imiquimod-induced psoriasis mouse model, MAP-F127/Cur demonstrated a significantly enhanced therapeutic effect.
Conclusion: : This study not only provides a new delivery strategy for Cur in the treatment of psoriasis, but also offers an important reference for designing transdermal delivery systems for other dermatological drugs.
Keywords: curcumin, mussel adhesive protein, pluronic F127 micelles, topical delivery, psoriasis
1College of Food and Drug, Luoyang Normal University, Luoyang, Henan, 471934, People’s Republic of China; 2College of Life Science, Luoyang Normal University, Luoyang, Henan, 471934, People’s Republic of China; 3Department of Research and Teaching, Luoyang Maternal and Child Health Hospital, Luoyang, Henan, 471000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Pei Zhang, Email zhangpei8877@126.com Xingang Cui, Email cuixingang5207@163.com
Background: Psoriasis is a long-term inflammatory skin disorder that significantly impacts the physical and psychological well-being of those affected. Curcumin (Cur) is a natural compound that holds promise for the topical management of psoriasis. However, the barrier property of the stratum corneum (SC) and the insufficient retention ability of the drug in the skin have severely restricted the clinical efficacy of Cur. To overcome these limitations, we introduced mussel adhesive protein (MAP) for its superior bioadhesive properties, and developed Cur-loaded MAP modified Pluronic F127 micelles (MAP-F127/Cur) to improve the skin permeation and retention of Cur and enhance the therapeutic effect on psoriasis.
Methods: In this study, MAP-F127 was synthesized via chemical synthesis. MAP-F127/Cur was prepared using the thin-film hydration method, and the physicochemical properties of the formulation were characterized. In addition, porcine skin was employed as an in vitro model to evaluate the skin permeation of the formulation and to elucidate the interaction mechanism between the formulation and the skin. Furthermore, the therapeutic efficacy of the formulation against psoriasis was assessed using an imiquimod-induced psoriasis mouse model.
Results: The prepared MAP-F127/Cur had a regular spherical shape and good dispersion, and could efficiently load Cur in the amorphous form. The skin retention of MAP-F127/Cur was notably elevated in comparison to both the Cur-loaded Pluronic F127 micelles (F127/Cur) and Cur solution (p< 0.01). Studies on the skin permeation mechanism showed that MAP-F127/Cur could break through the restriction of the skin barrier by regulating lipid arrangement and keratin conformation in the SC, forming a long-acting drug reservoir in the epidermal layer. Furthermore, in the imiquimod-induced psoriasis mouse model, MAP-F127/Cur demonstrated a significantly enhanced therapeutic effect.
Conclusion: : This study not only provides a new delivery strategy for Cur in the treatment of psoriasis, but also offers an important reference for designing transdermal delivery systems for other dermatological drugs.
Keywords: curcumin, mussel adhesive protein, pluronic F127 micelles, topical delivery, psoriasis