111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
术前炎症及肝纤维化标志物在肝细胞癌中的预后意义
Authors Cheng J , Pan Y, Li X, Lu M, Zhang Y, Wu J, Ye L, Liu X
Received 31 July 2025
Accepted for publication 20 November 2025
Published 9 December 2025 Volume 2025:18 Pages 17185—17196
DOI https://doi.org/10.2147/JIR.S557334
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Felix Marsh-Wakefield
Jianghao Cheng, Yajing Pan, Xiaoyu Li, Mengyu Lu, Yimin Zhang, Jie Wu, Liuqing Ye, Xin Liu
Department of Laboratory Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, People’s Republic of China
Correspondence: Xin Liu, Email liuxin2841@zjcc.org.cn
Purpose: Prognostic heterogeneity remains a challenge in hepatocellular carcinoma (HCC) following curative resection. Inflammatory markers such as the platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), prognostic nutritional index (PNI), and systemic inflammation response index (SIRI), as well as liver fibrosis markers including gamma-glutamyltransferase-to-lymphocyte ratio (GLR), gamma-glutamyltransferase-to-platelet ratio (GPR), and AST-to-ALT ratio (AAR), have shown prognostic potential. This study aimed to evaluate their predictive value for survival after resection.
Methods: We retrospectively analyzed 187 patients with HCC who underwent curative resection between 2008 and 2022. Preoperative inflammatory and fibrosis markers, along with clinical variables, were assessed using univariate and multivariate Cox regression for overall survival (OS) and disease-free survival (DFS). Kaplan-Meier analysis and nomogram models were used to estimate 1-, 3-, and 5-year survival.
Results: Multivariate analysis identified elevated SII, AAR, low PNI, tumor thrombus, and postoperative complications as independent predictors of poor OS, while only tumor thrombus and SIRI independently predicted DFS. SII, AAR, and PNI were also significantly associated with aggressive tumor characteristics. Patients with all three adverse markers (high SII, high AAR, low PNI) showed significantly poorer OS and DFS. A prognostic score incorporating these markers and nomogram models were constructed to predict OS and DFS after resection.
Conclusion: SII, AAR, and PNI are independent prognostic indicators for HCC following resection. The proposed prognostic score and nomograms may assist in individualized survival assessment and postoperative decision-making.
Keywords: systemic immune-inflammation index, prognostic nutritional index, AST-to-ALT ratio, hepatectomy
Department of Laboratory Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, People’s Republic of China
Correspondence: Xin Liu, Email liuxin2841@zjcc.org.cn
Purpose: Prognostic heterogeneity remains a challenge in hepatocellular carcinoma (HCC) following curative resection. Inflammatory markers such as the platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), prognostic nutritional index (PNI), and systemic inflammation response index (SIRI), as well as liver fibrosis markers including gamma-glutamyltransferase-to-lymphocyte ratio (GLR), gamma-glutamyltransferase-to-platelet ratio (GPR), and AST-to-ALT ratio (AAR), have shown prognostic potential. This study aimed to evaluate their predictive value for survival after resection.
Methods: We retrospectively analyzed 187 patients with HCC who underwent curative resection between 2008 and 2022. Preoperative inflammatory and fibrosis markers, along with clinical variables, were assessed using univariate and multivariate Cox regression for overall survival (OS) and disease-free survival (DFS). Kaplan-Meier analysis and nomogram models were used to estimate 1-, 3-, and 5-year survival.
Results: Multivariate analysis identified elevated SII, AAR, low PNI, tumor thrombus, and postoperative complications as independent predictors of poor OS, while only tumor thrombus and SIRI independently predicted DFS. SII, AAR, and PNI were also significantly associated with aggressive tumor characteristics. Patients with all three adverse markers (high SII, high AAR, low PNI) showed significantly poorer OS and DFS. A prognostic score incorporating these markers and nomogram models were constructed to predict OS and DFS after resection.
Conclusion: SII, AAR, and PNI are independent prognostic indicators for HCC following resection. The proposed prognostic score and nomograms may assist in individualized survival assessment and postoperative decision-making.
Keywords: systemic immune-inflammation index, prognostic nutritional index, AST-to-ALT ratio, hepatectomy