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已发表论文
18F-氟代脱氧葡萄糖正电子发射断层显像/计算机断层扫描（18F-FDG PET/CT）参数联合血清叉头框蛋白M1（FOXM1）对结直肠癌淋巴结转移的诊断价值
Authors Zhu Y, Bo L, Li L, Sun Y, Wu B
Received 24 June 2025
Accepted for publication 25 October 2025
Published 8 December 2025 Volume 2025:20 Pages 2447—2455
DOI https://doi.org/10.2147/CIA.S538944
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Zhi-Ying Wu
Yuanqing Zhu,1,* Lei Bo,2,* Lin Li,1 Yinggang Sun,1 Bo Wu1
1Department of Gastrointestinal Surgery, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, People’s Republic of China; 2Department of Clinical Laboratory, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Bo Wu, Email nbb8188@163.com
Objective: To evaluate the diagnostic value of maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), and metabolic tumor volume (MTV) in 18F-FDG PET/CT combined with serum forkhead box protein M1 (FOXM1) for detecting lymph node metastasis (LNM) in colorectal cancer (CRC).
Methods: A retrospective study was conducted on 107 CRC patients who underwent 18F-FDG PET/CT and serum FOXM1 testing, with postoperative pathology as the reference standard. Patients were divided into LNM-positive (n=52) and LNM-negative (n=55) groups. PET/CT metabolic parameters (SUVmax, TLG, MTV) and serum FOXM1 levels were compared, correlations were analyzed by Spearman’s test, and receiver operating characteristic (ROC) curves were plotted to assess diagnostic efficacy.
Results: SUVmax was significantly higher in LNM-negative patients, whereas TLG, MTV, and serum FOXM1 were higher in LNM-positive patients (all P< 0.05). Serum FOXM1 showed negative correlation with SUVmax (r=− 0.356) and positive correlation with TLG and MTV (r=0.564, 0.549). The combined model of SUVmax, TLG, MTV, and FOXM1 yielded the highest diagnostic performance (AUC=0.971, sensitivity=92.2%, specificity=94.3%).
Conclusion: SUVmax, TLG, MTV, and FOXM1 are interrelated and, when combined, provide superior diagnostic value for CRC LNM, though validation in larger, multicenter cohorts is needed.
Keywords: 18F-FDG PET/CT, SUVmax, TLG, MTV, serum FOXM1, colorectal cancer, lymph node metastasis
1Department of Gastrointestinal Surgery, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, People’s Republic of China; 2Department of Clinical Laboratory, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Bo Wu, Email nbb8188@163.com
Objective: To evaluate the diagnostic value of maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), and metabolic tumor volume (MTV) in 18F-FDG PET/CT combined with serum forkhead box protein M1 (FOXM1) for detecting lymph node metastasis (LNM) in colorectal cancer (CRC).
Methods: A retrospective study was conducted on 107 CRC patients who underwent 18F-FDG PET/CT and serum FOXM1 testing, with postoperative pathology as the reference standard. Patients were divided into LNM-positive (n=52) and LNM-negative (n=55) groups. PET/CT metabolic parameters (SUVmax, TLG, MTV) and serum FOXM1 levels were compared, correlations were analyzed by Spearman’s test, and receiver operating characteristic (ROC) curves were plotted to assess diagnostic efficacy.
Results: SUVmax was significantly higher in LNM-negative patients, whereas TLG, MTV, and serum FOXM1 were higher in LNM-positive patients (all P< 0.05). Serum FOXM1 showed negative correlation with SUVmax (r=− 0.356) and positive correlation with TLG and MTV (r=0.564, 0.549). The combined model of SUVmax, TLG, MTV, and FOXM1 yielded the highest diagnostic performance (AUC=0.971, sensitivity=92.2%, specificity=94.3%).
Conclusion: SUVmax, TLG, MTV, and FOXM1 are interrelated and, when combined, provide superior diagnostic value for CRC LNM, though validation in larger, multicenter cohorts is needed.
Keywords: 18F-FDG PET/CT, SUVmax, TLG, MTV, serum FOXM1, colorectal cancer, lymph node metastasis