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已发表论文
碳纳米材料在生物医学领域的应用机遇与毒理学考量
Authors Hou Y , Zhu C , Shen Z, Xu Y, Zhou S, Zhou X
Received 8 July 2025
Accepted for publication 21 November 2025
Published 8 December 2025 Volume 2025:20 Pages 14707—14730
DOI https://doi.org/10.2147/IJN.S552319
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. RDK Misra
Yingze Hou,1,2,* Can Zhu,3,* Zhean Shen,4 Yongan Xu,5 Shiwei Zhou,6 Xianchun Zhou1,2
1Central Laboratory, The Affiliated Hospital of Yanbian University, Yanji, 133000, People’s Republic of China; 2Department of Oncology, Yanbian Hospital Affiliated to Yanbian University, Yanji, 133000, People’s Republic of China; 3Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230032, People’s Republic of China; 4Department of Emergency Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215000, People’s Republic of China; 5Department of Emergency Medicine, The Second Affiliated Hospital & Institute of Emergency Medicine, Zhejiang University School of Medicine, Hangzhou, 310009, People’s Republic of China; 6Department of Emergency Medicine, Shaoxing People’s Hospital, Shaoxing, 312000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xianchun Zhou, Central Laboratory, The Affiliated Hospital of Yanbian University, Yanji, 133000, People’s Republic of China, Email xczhou@ybu.edu.cn
Abstract: Carbon nanomaterials have garnered significant interest from researchers acROSs various disciplines, primarily due to their high specific surface area, versatile surface chemical modifications, and exceptional optical properties. Notable carbon nanomaterials include graphene, carbon nanotubes, and carbon quantum dots, each exhibiting distinct potential applications within the biomedical domain. Extensive research over the years has positioned these diverse carbon nanoparticles as promising candidates for drug delivery, cancer diagnosis and therapy, tissue engineering, and biosensing, among other applications. Nonetheless, the issue of toxicity associated with carbon nanomaterials presents a pressing challenge that necessitates resolution. Empirical studies indicate that the size, aggregation state, and surface functionalization of carbon nanotubes can influence the biotoxicity and immunotoxicity of carbon nanoparticles within biological systems, thereby impacting their clinical translation and application. To advance the application and clinical translation of carbon nanomaterials within the biomedical field, this review will focus on carbon quantum dots, carbon nanotubes, graphene nanoparticles, and other carbon-based nanomaterials. It will provide a comprehensive summary of their application progress in the biomedical sector, as well as an analysis of their biotoxicity and immunotoxic responses. This synthesis aims to facilitate the clinical translation and application of carbon nanomaterials.
Keywords: biomedical applications, biotoxicity, biocompatibility, carbon nanomaterials, immunotoxicity
1Central Laboratory, The Affiliated Hospital of Yanbian University, Yanji, 133000, People’s Republic of China; 2Department of Oncology, Yanbian Hospital Affiliated to Yanbian University, Yanji, 133000, People’s Republic of China; 3Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230032, People’s Republic of China; 4Department of Emergency Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215000, People’s Republic of China; 5Department of Emergency Medicine, The Second Affiliated Hospital & Institute of Emergency Medicine, Zhejiang University School of Medicine, Hangzhou, 310009, People’s Republic of China; 6Department of Emergency Medicine, Shaoxing People’s Hospital, Shaoxing, 312000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xianchun Zhou, Central Laboratory, The Affiliated Hospital of Yanbian University, Yanji, 133000, People’s Republic of China, Email xczhou@ybu.edu.cn
Abstract: Carbon nanomaterials have garnered significant interest from researchers acROSs various disciplines, primarily due to their high specific surface area, versatile surface chemical modifications, and exceptional optical properties. Notable carbon nanomaterials include graphene, carbon nanotubes, and carbon quantum dots, each exhibiting distinct potential applications within the biomedical domain. Extensive research over the years has positioned these diverse carbon nanoparticles as promising candidates for drug delivery, cancer diagnosis and therapy, tissue engineering, and biosensing, among other applications. Nonetheless, the issue of toxicity associated with carbon nanomaterials presents a pressing challenge that necessitates resolution. Empirical studies indicate that the size, aggregation state, and surface functionalization of carbon nanotubes can influence the biotoxicity and immunotoxicity of carbon nanoparticles within biological systems, thereby impacting their clinical translation and application. To advance the application and clinical translation of carbon nanomaterials within the biomedical field, this review will focus on carbon quantum dots, carbon nanotubes, graphene nanoparticles, and other carbon-based nanomaterials. It will provide a comprehensive summary of their application progress in the biomedical sector, as well as an analysis of their biotoxicity and immunotoxic responses. This synthesis aims to facilitate the clinical translation and application of carbon nanomaterials.
Keywords: biomedical applications, biotoxicity, biocompatibility, carbon nanomaterials, immunotoxicity