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已发表论文
1990 年至 2021 年全球、区域和国家范围内孕产妇高血压疾病负担及趋势：一项基于人群的研究
Received 1 July 2025
Accepted for publication 24 November 2025
Published 6 December 2025 Volume 2025:17 Pages 5237—5248
DOI https://doi.org/10.2147/IJWH.S550876
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Matteo Frigerio
Li Yang,1 Wenting Xu2
1Department of Obstetrics and Gynaecology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, People’s Republic of China; 2Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Jiangsu Medical College, Zhangjiagang, Jiangsu, People’s Republic of China
Correspondence: Wenting Xu, Email zjgzyxwt@njucm.edu.cn
Objective: This study aimed to comprehensively assess the global, regional, and national burden and trends of maternal hypertensive disorders (MHD) from 1990 to 2021.
Methods: By analyzing MHD data from 1999 to 2021, age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years (ASDR) were screened, and estimated annual percentage change (EAPC) was calculated. This study used joinpoint regression analysis to examine trends during the period. This study investigated the differences in the burden of MHD among different Socio-demographic Index (SDI) regions through health inequalities analysis. Finally, we used the Bayesian age-period-cohort (BAPC) model to predict the trend in incidence, mortality, and DALYs rates of MHD over the next 25 years.
Results: The results showed that in 2021, the global ASIR, ASMR and ASDR were 461.94, 0.97 and 63.47, respectively (per 100000 population). From 1990 to 2021, the EAPC results showed a decreasing trend in the global ASIR, ASMR, and ASDR of MHD. The joinpoint regression results showed that the global ASIR, ASMR, and ASDR of MHD showed an overall downward trend from 1990 to 2021. Countries with lower SDI levels bore a higher burden. The predicted incidence, mortality, and DALYs rates of MHD for the next 25 years are both showing a downward trend.
Conclusion: The global ASIR, ASMR, and ASDR of MHD were all showing a downward trend from 1990 to 2021. However, this study found that Africa and low SDI regions bore a significant burden. The disparity in economic development could lead to an exacerbation of health inequalities. Therefore, it was emphasized that relevant public health policies should be formulated for African and low SDI regions. Medical staff should raise awareness of the risks of MHD and actively handle emergencies caused by MHD to reduce mortality, and DALYs rates and alleviate social burden.
Keywords: maternal hypertensive disorders, GBD 2021, disability-adjusted life years, health inequality, epidemiology
1Department of Obstetrics and Gynaecology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, People’s Republic of China; 2Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Jiangsu Medical College, Zhangjiagang, Jiangsu, People’s Republic of China
Correspondence: Wenting Xu, Email zjgzyxwt@njucm.edu.cn
Objective: This study aimed to comprehensively assess the global, regional, and national burden and trends of maternal hypertensive disorders (MHD) from 1990 to 2021.
Methods: By analyzing MHD data from 1999 to 2021, age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years (ASDR) were screened, and estimated annual percentage change (EAPC) was calculated. This study used joinpoint regression analysis to examine trends during the period. This study investigated the differences in the burden of MHD among different Socio-demographic Index (SDI) regions through health inequalities analysis. Finally, we used the Bayesian age-period-cohort (BAPC) model to predict the trend in incidence, mortality, and DALYs rates of MHD over the next 25 years.
Results: The results showed that in 2021, the global ASIR, ASMR and ASDR were 461.94, 0.97 and 63.47, respectively (per 100000 population). From 1990 to 2021, the EAPC results showed a decreasing trend in the global ASIR, ASMR, and ASDR of MHD. The joinpoint regression results showed that the global ASIR, ASMR, and ASDR of MHD showed an overall downward trend from 1990 to 2021. Countries with lower SDI levels bore a higher burden. The predicted incidence, mortality, and DALYs rates of MHD for the next 25 years are both showing a downward trend.
Conclusion: The global ASIR, ASMR, and ASDR of MHD were all showing a downward trend from 1990 to 2021. However, this study found that Africa and low SDI regions bore a significant burden. The disparity in economic development could lead to an exacerbation of health inequalities. Therefore, it was emphasized that relevant public health policies should be formulated for African and low SDI regions. Medical staff should raise awareness of the risks of MHD and actively handle emergencies caused by MHD to reduce mortality, and DALYs rates and alleviate social burden.
Keywords: maternal hypertensive disorders, GBD 2021, disability-adjusted life years, health inequality, epidemiology